Novel indole carboxamides

ABSTRACT

Novel indole-carboxamides of the formula ##STR1## wherein R and R 1  are individually selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms and aralkyl of 7 to 12 carbon atoms optionally substituted with 1 to 3 members of the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, --CF 3 , CH 3  S--, --NH 2  and --NO 2  or R 1  and R taken together with the nitrogen atom form an optionally unsaturated heterocycle optionally containing a member of the group consisting of --O--, --S-- and ##STR2## R&#39; is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, phenyl, naphthyl, aralkyl of 7 to 12 carbon atoms and substituted phenyl, R 3  is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 3 carbon atoms, chlorine, bromine, iodine --NO 2 , --NH 2 , acylamide of an aliphatic carboxylic acid of 2 to 5 carbon atoms and mono and dialkylamino with alkyl of 1 to 5 carbon atoms, a and b form ═0 and c is hydrogen or a and c form a carbon-carbon bond and b is hydrogen, A is selected from the group consisting of --(CH 2 ) n  -- and ##STR3## n is an integer from 2 to 5, m is an integer from 1 to 3, B is ##STR4## R 2  is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having remarkable anti-arrhythmic properties.

PRIOR APPLICATION

This application is a division of U.S. patent application Ser. No. 136,118 filed Dec. 21, 1987, now U.S. Pat. No. 4,908,367 which is a continuation-in-part of copending U.S. patent application Ser. No. 883,915 filed July 10, 1986, now U.S. Pat. No. 4,791,109.

STATE OF THE ART

Related indoles are described in copending U.S. patent application Ser. No. 498,835 filed May 27, 1983, now abandoned, Ser. No. 853,030 filed Apr. 17, 1986, now abandoned and Ser. No. 691,163 filed Jan. 14, 1985, now U.S. Pat. No. 4,650,811 and U.S. Pat. No. 4,333,951 and European Patent No. 89,426.

OBJECTS OF THE INVENTION

It is an object of the invention to provide the novel indole-carboxamides of formula I and their non-toxic, pharmaceutically acceptable acid addition salts and a novel process for their preparation.

It is another object of the invention to provide anti-arrythmic compositions and to a novel method of inducing anti-arrythmic activity in warm-blooded animals.

These and other objects and advantages of the invention will become obvious from the following detailed description.

THE INVENTION

The novel compounds of the invention are selected from the group consisting of indole-carboxamides of the formula ##STR5## wherein R and R₁ are individually selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms and aralkyl of 7 to 12 carbon atoms optionally substituted with 1 to 3 members of the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, --CF₃, CH₃ S--, --NH₂ and --NO₂ or R₁ and R taken together with the nitrogen atom form an optionally unsaturated heterocycle optionally containing a member of the group consisting of --O--, --S-- and ##STR6## R' is selected from the group consisting of hydrogen, alkyl or 1 to 5 carbon atoms, phenyl, naphthyl, aralkyl of 7 to 12 carbon atoms and substituted phenyl, R₃ is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 3 carbon atoms, chlorine, bromine, iodine --NO₂, --NH₂, acylamide of an aliphatic carboxylic acid of 2 to 5 carbon atoms and mono and dialkylamino with alkyl of 1 to 5 carbon atoms, a and b form ═O and c is hydrogen or a and c form a carbon--carbon bond and b is hydrogen, A is selected from the group consisting of --(CH₂)_(n) -- and ##STR7## n is an integer from 2 to 5, m is an integer from 1 to 3, B is ##STR8## R₂ is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms and their non-toxic pharmaceutically acceptable acid addition salts.

In the compounds of formula I, examples of linear and branched alkyl are methyl, ethyl, propyl, isopropyl and tert.-butyl. Examples of cycloalkyl of 3 to 7 carbon atoms are cyclopropyl, cyclobutyl, cyclohexyl and preferably cyclopentyl; examples of cycloalkylalkyl are cyclobutylmethyl and preferably cyclopropylmethyl. Examples of aralkyl of 7 to 12 carbon atoms are benzyl and phenethyl optionally substituted with 1 to 3 members of the group consisting of halogen methyl, ethyl, methoxy, ethoxy, CF₃ --, CH₃ S--, NH₂ and --NO₂. Examples of heterocycles formed by R and R₁ with the nitrogen atom to which they are attached are pyrrolidino, piperidino, morpholino, piperazinyl, methylpiperazinyl, ethylpiperazinyl and propylpiperazinyl. The substituted phenyl may be substituted with the same substituents as benzyl and phenethyl above.

Examples of alkoxy of 1 to 3 carbon atoms are methoxy, ethoxy, propoxy and isopropyoxy and examples of aliphatic acyls of 2 to 5 carbon atoms are acetyl and propionyl.

Examples of suitable acids for the formation of the non-toxic, pharmaceutically acceptable acid addition salts are inorganic acids such as hydrochloric acid, hydrobromic acid, nitric acid, sulfuric acid and phosphoric acid and organic acids such as formic acid, acetic acid, propionic acid, maleic acid, fumaric acid, succinic acid tartaric acid, citric acid, oxalic acid, glyoxylic acid, aspartic acid, alkane sulfonic acids such as methane sulfonic acid and ethane sulfonic acid, arylsulfonic acids such as benzene sulfonic acid or p-toluene sulfonic acid and arylcarboxylic acids such as benzoic acid.

Among the preferred compounds of formula I are those wherein R₂ is hydrogen, those wherein a and c form a double bond and those wherein R₃ is hydrogen, those wherein ##STR9## is in the ortho position and those wherein B is ##STR10## with the --NH-- next to the indole side and non-toxic, pharmaceutically acceptable acid addition salts.

In the compounds of formula I', the alkyl is preferably methyl, ethyl, n-propyl, isopropyl or tert.-butyl and the alkoxy is preferably methoxy, ethoxy or n-propoxy. In the alkylamino or dialkylamino moieties, the alkyls are preferably methyl or ethyl.

When X, X₁, X₂, X₃, X₄, X₅ and X₆ are halogen, they are preferably chlorine, but they can also be fluorine, bromine or iodine. The aliphatic acyl of 2 to 5 carbon atoms preferably is acetyl or propionyl. The alkenyl and alkynyl of 3 to 5 carbon atoms preferably is allyl or propargyl

Other preferred compounds of the invention are those of the formula ##STR11## wherein either R₂ and R₃ are both hydrogen, B is --CONH--, NH being on the indole side, b is hydrogen, a and c together form a second bond between the carbons which bear them, A is ##STR12## and either R₁ is hydrogen and R is selected from the group consisting of 1,1-dimethylpropyl, ##STR13## or R and R₁ together form with the nitrogen atom to which they are attached morpholino or R₂ and R₃ are both hydrogen, B is --CO--NH--, NH being on the indole side, b is hydrogen and a and c together form a second bond between the carbons which bear them, A is --(CH₂)₃ --, R₁ is hydrogen and R is selected from the group consisting of 1,1-dimethylpropyl, cyclohexyl, cyclohexylmethyl, propyl, isopropyl and ##STR14## or R₂ and R₃ are both hydrogen, B is NH--CO, ##STR15## being on the indole side, b is hydrogen and a and c together form a second bond between the carbons which bear them, A is --(CH₂)₃ --, R₁ is hydrogen and R is selected from the group consisting of cyclopentyl, cyclohexyl, 1,1-dimethylpropyl and ##STR16## or R₂ and R₃ are hydrogen, B is --NH--CO--, --NH being on the indole side, b is hydrogen and a and c together form a second bond between the carbons which bear them, A is --(CH₂)₄ --, R₁ is hydrogen and R is 1,1-dimethylethyl or R₂ is methyl and R₃ is hydrogen, B is --NH--CO--, NH being on the indole side, b is hydrogen and a and c together form a second bond between the carbons which bear them, A is ##STR17## and R is 1,1-dimethylethyl, or R₁ and R form, with the nitrogen atom to which they are attached ##STR18## in which Z is ##STR19## n₁ is 1,2 or 3 and X, X₁, X₂, X₃, X₄, X₅ and X₆ are individually selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 3 carbon atoms, halogen, nitro, amino, monoalkylamino or dialkylamino radical, with the proviso that X, X₁ and X₂ are not all three hydrogen, A is --(CH₂)_(n) -- n is 2,3,4 or 5 or ##STR20## in which m is 1,2 or 3, B is --CO--NH-- or --NH--CO--, R₃ is hydrogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 3 carbon atoms, chlorine, bromine or iodine, nitro or amino optionally substituted with an aliphatic acyl of 2 to 5 carbon atoms or with alkyl of 1 to 5 carbon atoms, a together with b is an oxo group, or together with c is a second bond between the carbons which bear them, b is hydrogen or together with a oxo, c is hydrogen or together with a is a second bond between the carbons which bear them, and R₂ is hydrogen, alkyl of 1 to 5 carbon atoms, alkenyl or alkynyl of 2 to 5 carbon atoms or aralkyl of 7 to 12 carbon atoms optionally substituted with 1,2 or 3 members of the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, methylthio, amino and nitro or cycloalkylalkyl or 4 to 7 carbon atoms.

The cycloalkylalkyl or 4 to 7 carbon atoms preferably is cyclopropylmethyl or cyclobutylmethyl. The aralkyl of 7 to 12 carbon atoms preferably is benzyl or phenethyl.

More preferred compounds of formula I' are those wherein R₁ and R together with the nitrogen form ##STR21## in which Z has the above meaning, A is ##STR22## or --(CH₂)₃ -- or --(CH₂)₄ --, R₃ is hydrogen, R₂ is hydrogen or methyl, b is hydrogen and a and c together form a second bond between the carbons which bear them.

Another preferred group of compounds having particularly interesting anti-arythmic activity are compounds of the formula, ##STR23## wherein one of X or Y is selected from the group consisting of alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 3 carbon atoms, chlorine, bromine, iodine, --NO₂, amino optionally substituted with acyl of 2 to 5 carbon atoms or one or two alkyls of 1 to 5 carbon atoms and the other is hydrogen with the proviso that Y is not methoxy when X is chlorine and their non-toxic, pharmaceutically acceptable acid addition salts.

Among preferred compounds of formula I" are those wherein Y is hydrogen and X is methoxy, --NH₂, amino or acetylamino and those wherein X is hydrogen and Y is chlorine, nitro, amino and acetylamino and their non-toxic, pharmaceutically acceptable acid addition salts.

Examples of specific preferred compounds of formula I are

2-[-[(1,1-dimethylethyl)amino]ethoxy]-N-(1H-indol-4-yl)benzamide,

2-[-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)benzamide

2-[3-[[bis-(1-methylethyl]amino]-2-hydroxypropoxyl]-N-(1H-indol-4-yl)benzamide and

2-[3-[(1,1-dimethylethyl)amino]propoxy]-N-(1H-indol-4-yl)benzamide,

2-[3-[(1,1-dimethylpropyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl) benzamide and its benzoate and its neutral oxalate,

2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-N-(1-methyl-1H-indol-4-yl)benzamide and its hydrochloride,

2-[2-hydroxy-3-[(1,1,3,3-tetramethylbutyl)amino]propoxy)-N-(1H-indol-4-yl)-benzamide,

2-[2-hydroxy-3[4-(diphenylmethyl)-1-piperazinyl]-propoxy)-N-(1H, indol-4-yl)benzamide and its neutral oxalate and 2-[3-(1,1-dimethylethyl)-amino]-2-hydroxy-propoxy-N-(1H-indol-4-yl)-5-nitro-benzamide and their non-toxic, pharmaceutically acceptable acid addition salts.

The novel process of the invention for the preparation of the compounds of formula I comprises reacting a compound of the formula ##STR24## wherein B, R₂ and R₃ have the above definitions with a halide of the formula

    G--Hal                                                     III

wherein Hal is chlorine, bromine or iodine and G is selected from the group consisting of ##STR25## wherein n and m have the above definitions and D is selected from the group consisting of chlorine, bromine, iodine, --OH and and a sulfonate of --OH to obtain a compound of the formula ##STR26## wherein B, R₂ and R₃ have the above definitions and G' is selected from the group consisting of ##STR27## reacting the latter with an amine of the formula ##STR28## wherein R and R₁ have the above definitions to obtain a compound of the formula ##STR29## wherein A, B, R, R₁, R₂ and R₃ have the above definitions which may be isolated and/or salified or when one of R and R₁ is hydrogen, the latter is subjected to an alkylation reaction or reacted with a halogenating agent to obtain a compound of the formula ##STR30## wherein Hal₁ is a bromine or chlorine and A, B, R, R₁, R₂ and R₃ have the above definitions and subjecting the latter to hydrolysis to obtain a compound of the formula ##STR31## wherein A,B,R,R₁, R₂ and R₃ have the above definitions which is isolated and, if desired, salified.

When A is a chain of the formula --(CH₂)_(n) --, a halide of formula III of the formula:

    Hal--(CH.sub.2).sub.n --D

is used wherein D is chlorine, bromine or iodine and Hal has the above significance. It it preferable that D and Hal should be two different halogens to avoid the condensation of two molecules of the compound of formula IV. Accordingly, for example, when D is a chlorine atom, a more reactive halide such as the bromide will be chosen for Hal.

When a hydroxylated halide of formula III has the formula

    HOt--(CH.sub.2).sub.n --Hal

in which n and Hal have the above definitions, it is preferred to operate in the presence of triphenyl phosphine and ethyl azodicarboxylate in tetrahydrofuran.

Advantageously, a sulfonate of this hydroxylated derivative is used, preferably, its tosylate of the formula

    TsO--(CH.sub.2).sub.n --Hal

wherein Ts represents a tosyl radical (4-methylbenzene sulfonate) and n and Hal have the above definitions. The operation is then done by phase transfer, using preferably as the aqueous phase an aqueous solution of an alkaline hydroxide such as potassium hydroxide or sodium hydroxide and as the organic phase non-miscible with water a solvent such as benzene in the presence of a transfer agent such as a quaternary ammonium salt of tetrabutyl ammonium, particularly the bromide or the hydrogenosulfate.

The reaction of the product of formula IV with the amine of formula V is carried out, for example, in an inert organic solvent such as dioxane, benzene, toluene, dimethylformamide, or even an alcohol, preferably ethanol, preferably in the presence of a condensation agent such as an alkali metal carbonate or bicarbonate like potassium carbonate, an alkali metal hydroxide like sodium hydroxide or potassium hydroxide, or a tertiary amine such as triethylamine. The operation can also be done utilizing directly the amine of formula V as solvent.

When A is ##STR32## a halide is used of the formula ##STR33## and in this case, Hal is preferably chlorine. The reaction of the derivative of formula II with the halide of formula III is then preferably carried out in the presence of a base such as potassium carbonate or sodium carbonate or sodium hydroxide or potassium hydroxide.

The reaction of the compound of formula IV in which G' is ##STR34## with the amine of formula V is carried out either directly using the amine as solvent, or by using a solvent such as an aliphatic alcohol like methanol or ethanol.

In the product of formula I_(A), the possible alkylation of the secondary amine of the lateral chain is carried out by the action of an alkyl halide in the presence of an alkali metal carbonate such as sodium or potassium carbonate in an organic solvent. When it is desired to carry out a methylation, it is preferred to use formaldehyde in the presence of a reducing agent such as sodium cyanoborohydride in a solvent such as an aliphatic alcohol such as methanol. Methyl p-toluene sulfonate can also be made to react in the presence of an alkali metal carbonate such as potassium or sodium carbonate in an organic solvent such as xylene.

The halogenation of the derivatives of formulae I_(A) can be carried out, for example with the brominated complex of pyridine of the formula ##STR35## in the case of bromination. It is advantageously carried out with a N-halo-succinimide, preferably the N-bromo or the N-chlorosuccinimide: the operation is done in dioxane or preferably in acetic acid. The product of formula VI obtained is preferably a chlorinated product.

The hydrolysis of the product of formula VI is carried out, preferably, with a mineral acid such as phosphoric acid, sulfuric acid, or preferably hydrochloric acid in aqueous solution. This solution can be used concentrated, but is preferably diluted, for example in normal solution. There can also be used a solvent such as an aliphatic alcohol like ethanol.

The compounds of formula II can be prepared as follows: To obtain a derivative of formula II_(A) ##STR36## wherein R₂ and R₃ have the above definition, the corresponding methyl ethyl indol-4-carboxylate or the corresponding indol-4-carboxylic acid is reacted with a derivative of aminophenol of the formula ##STR37## wherein K is hydrogen atom or a protective group of the hydroxy to obtain a compound of the formula ##STR38## wherein K and R₂ have the above definition wherein if necessary, the hydroxy function is freed to obtain the product of formula II_(A).

By protective group K of the hydroxy, a benzyl or a tosyl is intended, for example, but preferably tosyl. The reaction of methyl or ethyl indol-4-carboxylate with the derivative of formula VII is preferably carried out in the presence of triisobutylaluminum. The solvent utilized is preferably chloroform and the operation is advantageously carried out at reflux of the reaction mixture.

The reaction of indol-4-carboxylic acid with the derivative of formula VII is carried out in the presence of a dehydrating agent such as carbonyldiimidazole or preferably dicyclohexylcarbodiimide in a solvent such as tetrahydrofuran. The deblocking of the hydroxy of the compound of formula VIII is carried out by hydrogenolysis when K is benzyl, or by saponification when K is tosyl, preferably by means of sodium or potassium hydroxide in a solvent such as a low molecular weight alkanol such as methanol or preferably ethanol.

To obtain a derivative of the formula ##STR39## wherein R₂ and R₃ have the above definitions, the corresponding 4-amino indole is reacted with a methyl or ethyl carboxylate of the phenol or with hydroxy-benzoic acid to obtain the compound of formula II_(B). When a methyl or ethyl carboxylate of phenol is used, the operation is preferably done in the presence of triisobutylaluminum in a solvent such as chloroform and is done advantageously at reflux of the reaction mixture. When a methyl or ethyl carboxylate of phenol is used, the operation is done under identical conditions to those indicated for the preparation of the compound of formula II_(A) starting with methyl or ethyl indole-4-carboxylate. When hydroxy-benzoic acid is used, the operation is done in conditions identical to those indicated for the preparation of the compound of formula II starting with indol-4-carboxylic acid.

In a variation of the process for the preparation of the compounds of formula I wherein A is --(CH₂)_(n) --, a derivative of formula II reacted with a derivative of the formula ##STR40## wherein Hal, n, R and R₁ have the above definitions to obtain the compound of formula I_(A) which is converted, if desired, into the corresponding product of formula I_(B). The derivative of formula IX is reacted in the form of a free amine or, preferably, in the form of a salt like a hydrochloride.

In another variation of process for the preparation of the compounds of formula I wherein R₃ is an optionally substituted amino radical, the derivative in which R₃ is nitro is reduced and, if desired, the amino derivative is reacted with a reactive derivative of the substituent which is intended to be introduced. The corresponding conditions of carrying out are known to one skilled in the art.

The compounds of formula I have a basic character and the addition salts of the compounds of formula I can be prepared advantageously by reacting a mineral or organic acid in essentially stoichiometric proportions with the said derivative of formula I. The salts can be prepared without isolating the corresponding bases.

The novel anti-arrythmic compositions of the invention are comprised of an anti-arrythmically effective amount of at least one compound of formula I and their non-toxic, pharmaceutically acceptable acid addition salts and an inert pharmaceutical carrier or excipient. The compositions may be in the form of tablets, dragees, gelules, capsules, granules, suppositories and injectable solutions or suspensions.

Examples of suitable excipients are talc, arabic gum, lactose, starch, magnesium stearate, cocoa butter, aqueous and non-aqueous vehicles, fatty bodies of animal or vegetable origin, paraffinic derivatives, glycols, diverse wetting agents, dispersants and emulsifiers and preservatives.

The compositions are useful for the treatment of cardiac insufficiency, all forms of angor and for the treatment of arrythmia.

Among the preferred compositions of the invention are those wherein in the active compound a and c form a double bond, those wherein the active compound R₂ is hydrogen, those wherein R₃ is hydrogen, those wherein ##STR41## is in the ortho position and those wherein B is ##STR42## with the --NH-- next to the indole and their non-toxic, pharmaceutically acceptable acid addition salts. Specific preferred compositions are those wherein the active ingredient is 2-[2-[(1,1-dimethylethyl)amino]ethoxy]-N-(1H-indol-4-yl)benzamide, 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxyl]-N-(1H-indol-4-yl)benzamide, 2-[3-[[bis-(1-methylethyl]-amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)benzamide, 2-[3-[(1,1-dimethylethyl)amino]propoxy]-N-(1H-indol-4-yl)benzamide, 2-[3-[(1,1-dimethylpropyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)benzamide and its benzoate and its neutral oxalate, 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxpropoxy]-N-(1-methyl-1H-indol-4-yl)benzamide and its hydrochloride, 2-[2-hydroxy-3-[(1,1,3,3-tetramethylbutyl)amino]propoxy]-N-(1H-indol-4-yl)benzamide, 2-[2-hydroxy-3-[4-(diphenylmethyl)-1-piperazinyl]-propoxy]-N-(1H-indol-4-yl)benzamide and its neutral oxalate and 2-[3-(1,1-dimethylethyl)amino]-2-hydroxy-propoxy-N-(1H-indol-4-yl)-5-nitro-benzamide and their pharmaceutically acceptable acid addition salts.

The novel method of the invention for inducing anti-arrythmic activity in warm-blooded animals, including humans, comprises administering to warm-blooded animals an anti-arrythmically effective amount of at least one compound of formula I and their non-toxic, pharmaceutically acceptable acid addition salts. The compounds may be administered orally, rectally or parenterally and the usual daily dose is 0.65 to 13.5 mg/kg of depending on the compound, method of administration and condition treated. For example, the compound of Example 5 may be administered orally at a daily dose of 3 to 12 mg/kg in for treatment of ventricular, supra-ventricular and junction arrythmia.

The novel intermediates of the invention have the formula ##STR43## in which B, R₂ and R₃ have the above definitions.

In addition to the products described in the examples, the following products constitute new products which are within the scope of the present invention: 2-[3-[(1,1-dimethylpropyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)benzamide, 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-N-(1-methyl-1H-indol-4-yl)benzamide and 2-[3-(4-morpholinyl)-2-hydroxypropoxy]-N-(1H-indol-4-yl)benzamide.

In the following examples there are described several preferred embodiments to illustrate the invention. However, it should be understood that the invention is not intended to be limited to the specific embodiments.

EXAMPLE 1 N-[2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-phenyl]-1H-indol-4-carboxyamide and its neutral oxalate STEP A N-[2-[(4-methylphenyl)sulfonyloxy]phenyl]-1H-indol-4-carboxamide

140 ml of triisobutylaluminum in solution in toluene at 1.1 mole/l were added to a solution of 18 g of 2-aminophenol-4-methylbenzenesulfonate in 300 ml of chloroform, and after stirring for 15 minutes, a solution of 12.15 g of methyl indol-4-carboxylate in 120 ml of chloroform was added. The mixture was refluxed for 20 hours and was then cooled to 0° to -10° C. and 500 ml of an N aqueous solution of hydrochloric acid were added with stirring over 15 minutes. The chloroform phase was then purified by chromatography over silica (eluent: methylene chloride) to obtain 25 g of N-[2-[(4-methylphenylsulfonyloxy]phenyl]-1H-indol-4-carboxamide melting at 135° C.

STEP B N-(2-hydroxyphenyl)-1H-indol-4-carboxamide

250 ml of a solution of potassium hydroxide in ethanol at 10 g per 100 ml were added to a suspension of 25 g of N-[2-[(4-methylphenyl)sulfonyloxy]phenyl]-1H-indol-4-carboxamide in 50 ml of ethanol at 95° C. with stirring under an inert atmosphere and the mixture was stirred for 21 hours. 1 liter of iced water was added, and the mixture was acidified with a concentrated aqueous solution of hydrochloric acid, followed by stirring for a further 15 minutes, filtering, drying and triturating at reflux in 1.5 liters of methylene chloride. After concentrating to about 300 ml, filtering and drying at 80° C. under reduced pressure, 13 g of N-(2-hydroxyphenyl)-1H-indol-4-carboxamide melting at ≃208° C. were obtained.

    ______________________________________                                         U.V. Spectrum (ethanol):                                                       ______________________________________                                         Max. at 230 nm                                                                              E.sub.1 .sup.1 = 1,012                                                                          ε = 25,500                               Infl. at 265 nm                                                                             E.sub.1 .sup.1 = 208                                              Max. at 304 nm                                                                              E.sub.1 .sup.1 = 564                                                                            ε = 14,200                               Infl. at 318 nm                                                                             E.sub.1 .sup.1 = 482                                              ______________________________________                                    

STEP C N-[2-[(2-oxiranyl)methoxy]phenyl]-indol-4-carboxamide

Under an inert atmosphere, a solution of 3 g of N-(2-hydroxyphenyl)-1H-indol-4-carboxamide and 1.65 g of potassium carbonate in 100 ml of acetone was refluxed for 24 hours with 4.7 ml of epichlorhydrin and after purifying by chromatography over silica (eluent: ethyl acetate-triethylamine, 9-1) and evaporating to dryness, the residue was triturated in pentane, then filtered and dried under reduced pressure at 60° C. to obtain 2.8 g of N-[2-[(2-oxiranyl)methoxy]phenyl]-1H-indol-4-carboxamide melting at 122° C.

STEP D N-[2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-1H-indol-4-carboxamide

A solution of 2.8 g of the product from Step C for 1 hour in 40 ml of ethanol and 7.6 ml of tert-butylamine was heated at 80° C. under an inert atmosphere with stirring and after purification by chromatography over silica (eluent: ethyl acetate-triethylamine, 9-1, then chloroform-methanol 5-5), 3.05 g of N-[2-[3-[(1,1-dimethylethyl)-amino]-2-hydroxypropoxy]phenyl-1H-indol-4-carboxamide were obtained (amorphous beige-colored powder).

2.9 g of said product dissolved in 300 ml of acetone was admixed with 480 mg of oxalic acid and the mixture was refluxed for 15 minutes. After concentration to about 200 ml, cooling, filtering and drying under reduced pressure at 80° C., 2.9 g of the oxalate products were obtained, and 2.35 g after crystallization from methanol melted at ≃200° C.

EXAMPLE 2 N-[2-[2-[(1,1-dimethylethyl)amino]ethoxy]phenyl]-1H-indol-4-carboxamide and its hydrochloride STEP A N-[2-(2-chloroethoxy)phenyl]-1H-indol-4-carboxamide

2.5 g of N-(2-hydroxyphenyl)-1H-indol-4-carboxamide in 100 ml of benzene and 50 ml of acetonitrile with 850 mg of n-tetra-butylammonium hydrogensulfate, 3.6 ml of 3-chloroethyl p-toluene sulfonate and 50 ml of 5N sodium hydroxide were heated with stirring at 60° C. under an inert atmosphere. After cooling and decanting and extraction with ethyl acetate, the extracts were purified by chromatography over silica (eluent: dichloroethane). Evaporation to dryness under reduced pressure at 50° C. yielded 1.65 g of N-[2-(2-chloroethoxy)phenyl]-1H-indol-4-carboxamide melting at ≃135° C.

STEP B N-[2-[2-[(1,1-dimethylethyl)amino]ethoxy]phenyl]-1H-indol-4-carboxamide

With stirring at a pressure of 2 bars, a solution of 2.3 g of the product from Step A in 40 ml of ethanol and 37.5 ml of tert-butylamine was heated at 120° C. for 24 hours. After dilution with 400 ml of water and 400 ml of ethyl acetate, the solution was alkalized with sodium hydroxide and saturated with potassium carbonate. The mixture was extracted with ethyl acetate and the crystals obtained were triturated with ether to obtain 2.3 g of N-[2-[2-[(1,1-dimethylethyl)amino]ethoxy]phenyl]-1H-indol-4-carboxamide melting at ≃148° C.

Formation of the hydrochloride

The said base was dissolved in 200 ml of ethyl acetate and a solution of hydrogen chloride in ethyl acetate was added until the pH was acidic. The mixture was refluxed for 15 minutes and after concentrating to about 100 ml, cooling, filtering, drying at 80° C. under reduced pessure and crystallizing from isopropanol, 2.15 g of N-[2-[2-[(1,1-dimethylethyl)amino]ethoxy]phenyl]-1H-indol-4-carboxamide hydrochloride melting at ≃260° C. were obtained.

    ______________________________________                                         U.V. Spectrum (ethanol):                                                       ______________________________________                                         Max. at 229 nm    E.sub.1 .sup.1 = 724                                                                      ε = 28,100                                Max. at 302 nm    E.sub.1 .sup.1 = 303                                                                      ε = 11.750                                ______________________________________                                    

EXAMPLE 3 N-[2-[3-[(1,1-dimethylethyl)amino]propoxy]phenyl]-1H-indol-4-carboxamide hydrochloride STEP A N-[2-(3-chloropropoxy)phenyl]-1H-indol-4-carboxamide

A solution of 2 g of N-(2-hydroxyphenyl)-1H-indol-4-carboxamide, 150 ml of tetrahydrofuran, 0.65 ml of 3-chloropropanol and 2.1 g of triphenylphosphine was prepared with stirring under an inert atmosphere and then slowly 1.2 ml of ethyl azodicarboxylate were added. The mixture was stirred for 3 hours after which 2.1 g of triphenylphosphine and 0.65 ml of 3-chloropropanol were added. Then, slowly, 1.2 ml of ethyl azodicarboxylate were added and the mixture was stirred for 16 hours. Then the mixture was evaporated to dryness and the residue was purified by chromatography over silica (eluent: methylene chloride). The solution was evaporated to dryness, triturated with isopropyl ether, filtered and dried under reduced pressure to obtain 1.3 g of N-[2-(3-chloropropoxy)phenyl]-1H-indol-4-carboxamide melting at ≃144° C.

STEP B N-[2-[3-[(1,1-dimethylethyl)amino]propoxy]phenyl]-1H-indol-4-carboxamide hydrochloride

3.1 g of the product of Step A were heated at 100° C. under a pressure of 2 bars with stirring in 60 ml of ethanol and 30 ml of tertbutylamine. After diluting with 200 ml of water, acidifying with a concentrated aqueous solution of hydrochloric acid, filtering and washing with water, then triturating first with ether then with hot acetone for 15 minutes at reflux, 2.9 g of N-[2-[3-[(1,1-dimethylethyl)amino]propoxy]phenyl]-1H-indol-4-carboxamide hydrochloride melting at ≃238° C. were obtained.

    ______________________________________                                         U.V. Spectrum (ethanol):                                                       ______________________________________                                         Max. at 227 nm    E.sub.1 .sup.1 = 709                                                                      ε = 28,400                                Infl. at 262 nm   E.sub.1 .sup.1 = 130                                         Max. at 301 nm    E.sub.1 .sup.1 = 327                                                                      ε = 13,100                                Infl. at 320 nm   E.sub.1 .sup.1 = 227                                         ______________________________________                                    

EXAMPLE 4 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)benzamide and its neutral oxalate STEP A 2-[N-(1H-indol-4-yl)amido]phenol

92 ml of a 1.1 mole/liter solution of triisobutylaluminum in toluene were added with stirring under an inert atmosphere to a solution of 6.6 g of 4-amino indole in 250 ml of chloroform and then 9.6 ml of methyl salicylate were added. The mixture was refluxed for 20 hours and then cooled to ambient temperature. 300 ml of N-hydrochloric acid and 300 ml of methylene chloride were added, followed by washing with water, drying over a desiccant, filtering, evaporating to dryness under reduced pressure at 50° C., triturating with ether, filtering and drying at 60° C. under reduced pressure to obtain 9.4 g of 2-[N-(1H-indol-4-yl)amido]phenol melting at ≃232° C.

    ______________________________________                                         U.V. Spectrum (ethanol):                                                       ______________________________________                                         Infl. at 216 nm   E.sub.1 .sup.1 = 1,595                                       Infl. at 233 nm   E.sub.1 .sup.1 = 680                                                                       ε = 17,200                               Infl. at 262 nm   E.sub.1 .sup.1 = 187                                         Infl. at 303 nm   E.sub.1 .sup.1 = 482                                                                       ε = 12,200                               Infl. at 314 nm   E.sub.1 .sup.1 = 494                                                                       ε = 12,500                               ______________________________________                                    

STEP B 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)benzamide and its neutral oxalate

Using the procedure of example 1, 3.5 g of 2-[N-(1H-indol-4-yl)amido]phenol were reacted to obtain 3 g of the oxalate melting at 190° C.

    ______________________________________                                         U.V. Spectrum (ethanol + HCl 0.1 N):                                           ______________________________________                                         Infl. at 216 nm                                                                               E.sub.1 .sup.1 = 1,003                                          Max. at 296 nm E.sub.1 .sup.1 = 264                                                                        ε = 11,300                                 Infl. at 235, 274, 288, 309 nm                                                 ______________________________________                                    

EXAMPLE 5 2-[2-[(1,1-dimethylethyl)amino]ethoxy]-N-(1H-indol-4-yl)-benzamide hydrochloride

Using the procedure of Example 2, 27 g of 2-[N-(1H-indol-4-yl)-amido]phenolbenzamide were reacted to obtain 4.4 g of 2-[2-[(1,1-dimethylethyl)amino]ethoxy]-N-(1H-indol-4-yl)-benzamide hydrochloride melting at ≃248° C.

    ______________________________________                                         U.V. Spectrum (ethanol or ethanol + HCl 0.1 N):                                ______________________________________                                         Infl. at 215 nm                                                                               E.sub.1 .sup.1 = 1,099                                                                      ε = 42,600                                 Max. at 293 nm E.sub.1 .sup.1 = 285                                                                        ε = 11,100                                 ______________________________________                                    

EXAMPLE 6 2-[3-[(1,1-dimethylethyl)amino]propoxy]-N-(1H-indol-4-yl)benzamide

Using the procedure of Example 3, 5 g of 2-[N-(1H-indol-4-yl)amido]-phenol benzamide were reacted to obtain 3.1 g of 2-[3-[(1,1-dimethylethyl)amino]propoxy]-N-(1H-indol-4-yl)benzamide melting at ≃146° C., then 3.1 g of its oxalate melting at ≃180° C.

    ______________________________________                                         U.V. Spectrum of the oxalate (ethanol):                                        ______________________________________                                         Infl. at 218 nm                                                                               E.sub.1 .sup.1 = 879                                            Max. at 297 nm E.sub.1 .sup.1 = 246                                                                        ε = 11,200                                 ______________________________________                                    

EXAMPLE 7 N-[2-[2-(1-piperidinyl)ethoxy]phenyl]-1H-indol-4-carboxamide

3 g of N-(2-hydroxyphenyl)-1H-indol-4-carboxamide in 50 ml of benzene, 25 ml of acetonitrile and 50 ml of a 5N aqueous solution of sodium hydroxide were heated to 60° C. for 3 hours with stirring under an inert atmosphere with 0.4 g of 2-tetrabutylammonium hydrogenosulfate and 2.2 g of 2-piperidino-1-chloroethane. After cooling, decanting, extracting with ethyl acetate and purifying by chromatography over silica (eluent: ethyl acetate-triethylamine, 9-1), 3.6 g of N-[2-[2-(1-piperdinyl)ethoxy]phenyl]-1H-indol-4-carboxamide were obtained.

Formation of the fumarate

The said base was dissolved in 100 ml of isopropanol and 1.15 g of fumaric acid were added. The mixture was refluxed and after cooling, filtering, and taking to dryness under reduced pressure, 3.80 g of the fumarate were obtained in two lots melting at ≃186° C. after crystallization from ethanol.

    ______________________________________                                         U.V. Spectrum:                                                                 ______________________________________                                         Infl. at 230 nm                                                                               E.sub.1 .sup.1 = 681                                            Infl. at 260 nm                                                                               E.sub.1 .sup.1 = 141                                            Max. at 300 nm E.sub.1 .sup.1 = 271                                                                        ε = 13,000                                 Infl. at 320 nm                                                                               E.sub.1 .sup.1 = 224                                            ______________________________________                                    

EXAMPLE 8 N-[2-[2-(dimethylamino)ethoxy]phenyl]-1H-indol-4-carboxamide

Using the procedure of Example 7, the hydrochloride of dimethylaminoethyl chloride was reacted to obtain 3.6 g of N-[2-[2-(dimethylamino)ethoxy]phenyl]-1H-indol-4-carboxamide melting at 110° C. then 4.4 g of tartrate (softening point--110° C.)

    ______________________________________                                         U.V. Spectrum of the tartrate (ethanol)                                        ______________________________________                                         Max. at 228 nm E.sub.1 .sup.1 = 559                                                                        ε = 26,500                                 Infl. at 263 nm                                                                               E.sub.1 .sup.1 = 123                                            Max. at 300 nm E.sub.1 .sup.1 = 261                                                                        ε = 12,400                                 ______________________________________                                    

EXAMPLE 9 N-[2-[2-[bis(1-methylethyl)amino]ethoxy]phenyl]-1H-indol-4-carbox amide

Using the procedure of Example 7, 8.5 g of the hydrochloride of diisopropylaminoethyl chloride were reacted to obtain 4 g of N-[2-[2-[bis(1-methylethyl)amino]ethoxy]phenyl]-1H-indol-4-carboxamide melting at 145° C. then 2.9 g of the hydrochloride melting at 214° C.

EXAMPLE 10 N-(1H-indol-4-yl)-2-[2-(1-piperidinyl)ethoxy]- benzamide

Using the procedure of Example 7, 2.5 g of 2-[N-(1H-indol-4-yl) amido]phenol and 1.84 g of 2-piperidine-1-chloroethane hydrochloride were reacted to obtain 3.0 g of N-(1H-indol-4-yl)-2-[2-(1-piperidinyl)ethoxy]-benzamide melting at 154° C. after crystallization from ethyl ether.

Formation of the phosphate

2.7 g of the said base were dissolved in 500 ml of ethanol and 10 ml of a 1M solution of phosphoric acid in ethanol were added. The mixture was heated to reflux and 500 ml of methanol were added. The reaction medium was filtered hot, partially concentrated and then cooled, filtered and dried under reduced pressure at 80° C. After crystallizing from an ethanol-methanol mixture (1-1), 2.4 g of the phosphate product melting 238° C. were obtained.

    ______________________________________                                         Analysis: C.sub.22 H.sub.25 N.sub.3 O.sub.2.H.sub.3 PO.sub.4 : molecular       weight = 461.458                                                               ______________________________________                                         Calculated:                                                                             % C 57.26 % H 6.12  % N 9.11                                                                               % P 6.71                                  Found:   57.1      6.2       9.0     6.6                                       ______________________________________                                    

EXAMPLE 11 2-[2-(dimethylamino)ethoxy]-N-(1H-indol-4-yl) benzamide

Using the procedure of Example 7, 2.5 g of 2-[N-(1H-indol-4-yl)amido]phenol and 1.44 g of dimethylaminoethyl chloride hydrochloride were heated for 24 hours to obtain 2.15 g of base melting at 138° C. after crystallization from ethyl ether.

Using the procedure of Example 10, 3.3 g of the said base and replacing the ethanol with isopropanol, 3.5 g of the phosphate product were obtained.

    ______________________________________                                         Analysis: C.sub.19 H.sub.21 N.sub.3 O.sub.2, H.sub.3 PO.sub.4 : molecular      weight = 421.37                                                                ______________________________________                                         Calculated:                                                                             % C 54.15 % H 5.70  % N 9.97                                                                               % P 7.35                                  Found:   53.8      5.8       9.8     7.3                                       ______________________________________                                    

EXAMPLE 12 2-[2-[bis(1-methylethyl)-amino]ethoxy-]N-(1H-indol-4-yl) benzamide

Using the procedure of Example 7, 3.5 g of 2-[N-(1H-indol-4-yl)amido]phenol and 2.8 g of diisopropylaminoethyl chloride hydrochloride were reacted to obtain 5.7 g of crude product which was purified by chromatography over silica (eluent:chloroform-acetonetriethylamine, 6-3-1) and crystallizing from chloroform, then from a mixture of isopropanol and methanol (2-1) to obtain 2.25 g of 2-[2-[bis (1-methylethyl)-amino]ethoxy-N-(1H-indol-4-yl) benzamide melting at 180° C.

    ______________________________________                                         Analysis: C.sub.23 H.sub.29 N.sub.3 O.sub.2 : molecular weight                 ______________________________________                                         = 379.48                                                                       Calculated:                                                                             % C 72.79   % H 7.70    % N 11.07                                     Found:   72.9        7.9         10.9                                          ______________________________________                                    

EXAMPLE 13 2-[2-hydroxy-3-(propylamino)-propoxy]-N-(1H-indol-4-yl) benzamide.

3.1 g of 2-[(2-oxiranyl) methoxy]-N-(1H-indol-4-yl) benzamide prepared as in example 4 is heated for 2 hours to reflux in 60 cm3 of ethanol and 8.5 cm3 of n-propylamine. The solvents are eliminated under reduced pressure at 50° C., the residue is chromatographed on silica (eluent: chloroform-methanol 7-3) to obtain 2.8 g of 2-[2-hydroxy-3-(propylamino)-propoxy]-N-(1H-indol-4-yl) benzamide.

1.7 g of the said base were dissolved in 200 ml of isopropanol and 100 ml of methanol at reflux, and 585 mg of oxalic acid were added. After partially concentrating the reaction medium, cooling, filtering and drying under reduced pressure at 80° C., 1.7 g of the oxalate product melting at 110° C. were obtained.

    ______________________________________                                         Analysis: C.sub.21 H.sub.25 N.sub.3 O.sub.3, C.sub.2 H.sub.2 O.sub.4 ;         molecular weight = 467.487                                                     ______________________________________                                         Calculated:                                                                             % C 60.39   % H 5.95    % N 9.18                                      Found:   60.2        6.0         9.2                                           ______________________________________                                    

EXAMPLE 14 N-(1H-indol-4-yl)-2-[2-hydroxy-3-[(1-methylethyl)-amino]propoxy]benzamide

Using the procedure of Example 13, 8.6 ml of isopropylamine were reacted to obtain 2.8 g of N-(1H-indol-4-yl)-2-[2-hydroxy-3-[(1-methylethyl)-amino]propoxy]benzamide.

Using the procedure of Example 13, 2.8 g of the said base and 960 mg of oxalic acid were reacted to obtain 1.7 g of the neutral oxalate product melting 190° C.

    ______________________________________                                         Analysis: C.sub.21 H.sub.25 N.sub.3 O.sub.3, 1/2 C.sub.2 H.sub.2 O.sub.4       : molecular weight = 412.469                                                   ______________________________________                                         Calculated:                                                                             % C 64.06   % H 6.35    % N 10.19                                     Found:   63.8        6.5         10.0                                          ______________________________________                                    

EXAMPLE 15 2-[3-[[bis(1-methylethyl)]amino]-2-hydroxypropoxy-N-(1H-indol-4-yl) benzamide

Using the procedure of Example 13, 14 ml of diisopropylamine were reacted while maintaining reflux for 5 hours to obtain 4 g of crude product which was chromatographed over silica (eluent:chloroform - ethyl acetate-triethylamine 6-3-1) and crystallized from ethyl acetate to obtain 2.4 g of 2-[3-[[bis(1-methylethyl)]amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl) benzamide melting at 160° C.

    ______________________________________                                         Analysis: C.sub.24 H.sub.31 N.sub.3 O.sub.3 ; molecular weight                 ______________________________________                                         = 409.533                                                                      Calculated:                                                                               % C 70.39 % H 7.63   % N 10.26                                      Found:     70.4      7.8        10.2                                           ______________________________________                                    

EXAMPLE 16 2-[3-(diethylamino)-2-hydroxypropoxy]-N-(1H-indol-4-yl) benzamide

Using the procedure or Example 13, 10 ml of diethylamine were reacted to obtain 3 g of 2-[3-(diethylamino)-2-hydroxypropoxy]-N-(1H-indol-4-yl) benzamide.

2.5 g of the said base were dissolved in 65.6 ml of 0.1N hydrochloric acid and 10 ml of methanol were added. The methanol was expelled under reduced pressure and the solution was lyophilized to obtain 2.67 g of the hydrochloride product.

    ______________________________________                                         Analysis: C.sub.22 H.sub.27 N.sub.3 O.sub.3 HCl: molecular weight =            417.939                                                                        ______________________________________                                         Calculated:                                                                             % C 63.23 % H 6.75 % N 10.05                                                                              % Cl 8.48                                  Found:   62.9      6.9      9.9     8.7                                        ______________________________________                                    

EXAMPLE 17 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl) benzamide benzoate

2 g of the base of Example 4 were dissolved in 200 ml of isopropanol at reflux, and 640 mg of benzoic acid were added. The solution was filtered hot, partially concentrated, cooled and filtered and the product obtained was dried under reduced pressure at 80° C. After crystallizing from isopropanol, 2.0 g of 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)benzamide benzoate melting at 190° C. were obtained.

    ______________________________________                                         Analysis: C.sub.22 H.sub.27 N.sub.3 O.sub.3, C.sub.7 H.sub.6 O.sub.2           Molecular weight = 503.603                                                     ______________________________________                                         Calculated:                                                                               % C 69.17 % H 6.61   % N 8.34                                       Found:     69.4      6.7        8.3                                            ______________________________________                                    

EXAMPLE 18 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-N-[2,3-dihydro-2-oxo-1H-indol-4-yl] benzamide and its neutral oxalate STEP A 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy-N-(3-chloro -1H-indol-4-yl) benzamide

A mixture of 3.3 g of the base of Example 4, 40 ml of acetic acid and 1.3 g of N-chloro-succinimide were stirred for 1 hour at ambient temperature and under an inert atmosphere. The reaction medium was diluted with water, alkalinized with ammonia and extracted with ethyl acetate. The solvents were eliminated under reduced pressure and the residue was chromatographed over silica (eluent:ethyl acetate - triethylamine, 9-1) to obtain 2.5 g of 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy-N-(3-chloro-1H-indol-4-yl) benzamide.

STEP B 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-N-[2,3-dihydro-2-oxo-1H-indol-4-yl] benzamide

2.5 g of the product of Step A in 35 ml of ethanol and 70 ml of 1N hydrochloric acid was refluxed for 1 hour and the reaction mixture was diluted with water, alkalinized with sodium hydroxide and extracted with ethyl acetate. After elimination of the solvent under reduced pressure, 2.5 g of crude product were obtained which crystallized spontaneously from a mixture of solvents:chloroform-ethyl acetate-triethylamine (6-3-1) to obtain 1.9 g of 2-[3[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-N-[2,3-dihydro-2-oxo-1H-indol-4-yl]-benzamide melting at 160° C.

1.9 g of the said base were dissolved in 300 ml of isopropanol and 100 ml of methanol at reflux, and 600 mg of oxalic acid were added. Reflux was maintained for 15 minutes, after which the reaction medium was cooled and partially concentrated. The crude expected product was cooled, filtered and dried under reduced pressure. After crystallizing from a mixture of isopropanol and methanol (1-3), 1.8 g of the oxalate were obtained melting at 234° C.

    ______________________________________                                         Analysis: C.sub.22 H.sub.27 N.sub.3 O.sub.4, 1/2 C.sub.2 H.sub.2 O.sub.4       : molecular weight = 442.495                                                   ______________________________________                                         Calculated:                                                                               % C 62.43 % H 6.38   % N 9.50                                       Found:     62.2      6.4        9.3                                            ______________________________________                                    

EXAMPLE 19 2-[3-(4-methyl-1-piperazinyl)-2-hydroxypropoxy]-N-(1H-indol-4-yl)-benzamide

1.8 g of 2-[(2-oxiranyl)methoxy]-N-(1H-indol-4-yl)-benzamide in 36 ml of ethanol and 6.5 ml of N-methyl piperazine was refluxed for 1 hour and the solvents were eliminated under reduced pressure. The residue was chromatographed over silica (eluent:chloroformethanol, 9-1) to obtain 1.77 g of 2-[3-(4-methyl-1-piperazinyl)-2-hydroxypropoxy]-N-(1H-indol-4-yl)-benzamid

1.7 g of the said base were dissolved in 100 ml of isopropanol and 524 mg of oxalic acid were added. The product obtained was filtered off and dried under reduced pressure at 70° C. After crystallizing from isopropanol, 0.96 g of the oxalate melting at 130° C. (decomposes) were obtained.

    ______________________________________                                         Analysis: C.sub.23 H.sub.28 N.sub.4 O.sub.3, C.sub.2 H.sub.2 O.sub.4           molecular weight = 498.54                                                      ______________________________________                                         Calculated:                                                                               % C 60.23 % H 6.07   % N 11.24                                      Found:     60.3      6.3        11.2                                           ______________________________________                                    

EXAMPLE 20 2-[3-[4-(2-methoxyphenyl)-1-piperazinyl]-2-hydroxypropoxy]-N-(1H-indol-4-yl)-benzamide

1.6 g of 2-[(2-oxiranyl)-methoxy]-N-(1H-indol-4-yl)]-benzamide in 36 ml of ethanol was refluxed for 4 hours with 1.82 ml of (methoxyphenyl)piperazine and the solvent was eliminated under reduced pressure. The residue was purified by chromatography over silica (eluent:chloroform - ethyl acetate - triethylamine, 6-3-1) to obtain 1.85 g of 2-[3-[4-(2-methoxyphenyl)-1-piperazinyl]-2-hydroxypropoxy]-N-(1H-indol-4-yl)-benzamide.

    ______________________________________                                         U.V. Spectrum (ethanol):                                                       ______________________________________                                         Infl. at 235 nm                                                                               E.sub.1.sup.1 = 449                                                                      ε =                                                                              22,400                                      Max. at 287 nm E.sub.1.sup.1 = 222                                                                      ε =                                                                              11,100                                      Infl. at 294 nm                                                                               E.sub.1.sup.1 = 215                                             Infl. at 310 nm                                                                               E.sub.1.sup.1 = 179                                                                      ε =                                                                               8,900                                      ______________________________________                                    

    ______________________________________                                         IR Spectrum (chloroform)                                                       ______________________________________                                         OH free       3600 cm.sup.-1                                                   CNH           3481 cm.sup.-1 - 3373 cm.sup.-1                                   ##STR44##    1661 cm.sup.-1                                                   CC + aromatic +                                                                              1623 cm.sup.-1 - 1600 cm.sup.-1 - 1587 cm.sup.-1                 amide II      1538 cm.sup.-1 - 1500 cm.sup.-1 - 1485 cm.sup.-1                 ______________________________________                                    

EXAMPLE 21 2-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)-benzamide

4 g of 2-[(2-oxiranyl)methoxy]-N-(1H-indol-4-yl)-benzamide in 48 ml of ethanol were refluxed for 1 hour with 6.57 ml of dimethoxyphenyl ethylamine and the solvent was eliminated under reduced pressure. The residue was purified by chromatography over silica (eluent:chloroform - methanol, 9-1) to obtain 4.60 g of 2-[3-[[2-(3,4-dimethoxyphenyl)ethyl]-amino]-2-hydroxypropoxy]-(1H-indol-4-yl)-benzamide.

    ______________________________________                                         U.V. Specturm (ethanol):                                                       ______________________________________                                         Infl. at 218 nm                                                                               E.sub.1.sup.1 = 921                                             Infl. at 230 nm                                                                               E.sub.1.sup.1 = 528                                                                      ε =                                                                              25,800                                      Max. at 288 nm E.sub.1.sup.1 = 222                                                                      ε =                                                                              10,900                                      Max. at 299 nm E.sub.1.sup.1 = 211                                                                      ε =                                                                              10,300                                      Infl. at 310 nm                                                                               E.sub.1.sup.1 = 187                                                                      ε =                                                                               9,150                                      ______________________________________                                    

    ______________________________________                                         IR Spectrum (chloroform)                                                       ______________________________________                                         secondary amide NH                                                                               3360 cm.sup.-1                                               CO                1659 cm.sup.-1                                               amide II          1534 cm.sup.-1                                               aromatic          1623 cm.sup.-1 - 1601 cm.sup.-1 -                                              1587 cm.sup.-1                                                ##STR45##        1516 cm.sup.-1                                               methoxy           2837 cm.sup.-1                                               ______________________________________                                    

EXAMPLE 22 2-[3-(cyclohexylamino)-2-hydroxypropoxy]-N-(1H-indol-4-yl)-benzamide

2.5 g of 2-[(2-oxiranyl)methoxy]-N-(1H-indol-4-yl)-benzamide in 20 ml of ethanol was refluxed for 2 hours with 1.86 ml of cyclohexylamine and the solvent was eliminated under reduced pressure. The residue was chromatographed over silica (eluent:chloroform-methanol 9-1) to obtain 1.97 g of 2-[3-(cyclohexylamino)-2-hydroxypropoxy]-N-(1H-indol-4-yl)-benzamide

    ______________________________________                                         U.V. Spectrum (ethanol):                                                       ______________________________________                                         Infl. at 216 nm E.sub.1.sup.1 = 832                                            Infl. at 234 nm E.sub.1.sup.1 = 320                                            Infl. at 270 nm E.sub.1.sup.1 = 113                                            Max. at 296 nm  E.sub.1.sup.1 = 212                                                                      ε = 8,650                                    Infl. at 304 nm E.sub.1.sup.1 = 199                                            ______________________________________                                    

    ______________________________________                                         IR Spectrum (chloroform):                                                      ______________________________________                                         NH indole    3480 cm.sup.-1                                                    Amide        1660 cm.sup.-1                                                    Amide II     1536 cm.sup.-1                                                    Aromatics:   1624 cm.sup.-1 - 1600 cm.sup.-1 -                                              1588 cm.sup.-1 - 1503 cm.sup.-1 - 1485 cm.sup.-1                  ______________________________________                                    

EXAMPLE 23 4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)-benzamide STEP A 4-[N-(1H-indol-4-yl)amido]phenol

Under an inert atmosphere, 42 ml of tri-isobutylaluminum in solution in toluene (1.1M) were added slowly to a solution of 3 g of 4-amino-indole in 100 ml of chloroform and 3.5 g of methyl p-hydroxybenzoate in 50 ml of chloroform were then added, followed by reflux for 24 hours. After cooling, 200 ml of 2N hydrochloric acid were added with stirring for 30 minutes and the precipitate was filtered off, washed with water and dried under reduced pressure at 80° C. to obtain 4.9 g of 4-[N-(1H-indol-4-yl)amido/phenol.

    ______________________________________                                         U.V. Spectrum (ethanol):                                                       ______________________________________                                         Max. at 212 nm E.sub.1.sup.1 =                                                                        1455   ε = 36,700                               Max. at 256 nm E.sub.1.sup.1 =                                                                         557   ε = 14,000                               Max. at 277 nm E.sub.1.sup.1 =                                                                         438   ε = 11,000                               Max. at 284 nm E.sub.1.sup.1 =                                                                         444   ε = 11,200                               Infl. at 294 nm                                                                               E.sub.1.sup.1 =                                                                         432                                                    ______________________________________                                    

STEP B 4-[(2-oxiranyl)methoxy]-N-(1H-(indol-4-yl)]-benzamide

Using the procedure of Example 1, 5.37 g of 4-[N-(1H-indol-4-yl)amido]phenol and 25.8 ml of epichlorhydrin were reacted and after chromatography over silica (eluent:chloroform - ethyl acetate triethylamine 6-3-1) and triturating in isopropyl ether, 2.9 g of 4[(2-oxiranyl)methoxy]-N-(1H-(indol-4-yl)]-benzamide melting at 170° C. were recovered.

STEP C 4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)-benzamide

Using the procedure of Step B of Example 1, 2.9 g of the product of Step B were reacted to obtain 3.5 g of 4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)-benzamide melting at 212° C.

2.9 g of the said base were dissolved in 300 ml of isopropanol at reflux, and 0.88 g of fumaric acid and then 200 ml of methanol were added. Reflux was continued for 30 minutes and the reaction medium was partially concentrated, then cooled and filtered under reduced pressure at 80° C. to obtain 2.3 g of crude product. After crystallization from an ethanol-methanol-water mixture (10-10-1), 1.8 g of the neutral fumarate melting >270° C. were obtained.

    ______________________________________                                         Analysis: C.sub.22 H.sub.27 N.sub.3 O.sub.2, 1/2 C.sub.4 H.sub.4 O.sub.4       : molecular weight = 439.516                                                   ______________________________________                                         Calculated:                                                                               % C 65.59 % H 6.65   % N 9.56                                       Found:     65.3      6.7        9.6                                            ______________________________________                                    

EXAMPLE 24 4-chloro-2[3-[(1,1-dimethylamino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)-benzamide STEP A 5-chloro-2-[N-(1H-indol-4-yl)amido]phenol

Under an inert atmosphere, a solution of 5.28 g of 4-chlorosalicyclic acid and 9.06 g of dicyclohexylcarbodiimide was heated to reflux and the dicyclohexylurea formed was filtered off. The solvent was expelled under reduced pressure at 50° C. and after chromatography over silica (eluent:chloroform - ethyl acetate, 9-1), the residue was triturated with ether and dried to obtain 5.55 g of 5-chloro-2-[N-(1H-indol-4-yl) amido]phenol melting at 245° C.

    ______________________________________                                         Analysis: C.sub.15 H.sub.11 N.sub.2 ClO.sub.2 : Molecular weight =             ______________________________________                                         286.720                                                                        Calculated:                                                                             % C 62.84 % H 3.87 % N 9.77                                                                               % Cl 12.36                                 Found:   62.5      4.0      9.7     12.3                                       ______________________________________                                    

STEP B 4-chloro-2-[(2-oxiranyl)methoxy]-N-(1H-indol-4-yl)-benzamide

Under an inert atmosphere, a solution of 4.5 g of 5-chloro-2-[N-(1H-indol-4-yl)] amido phenol in 150 ml of acetone was heated to reflux with 2.2 g of potassium carbonate and 12.5 ml of epichlorhydrin and the product crystallized out of the reaction medium. The solvent was eliminated under reduced pressure at 50° C. and the residue was taken up in water, filtered and dried under reduced pressure at 80° C. to obtain 5 g of 4-chloro-2[(2-oxiranyl)methoxy]-N-(1H-indol-4-yl)-benzamide melting at 194° C.

STEP C 4-chloro-2-[3-[(1,1-dimethylethylamino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)-benzamide

3 g of the product of Step B was refluxed for 2 hours in 100 ml of ethanol and 7.6 ml of terbutylamine and the solvent was expelled under reduced pressure at 50° C. After chromatography over silica (eluent:chloroform-methanol-triethyamine 8-1-1), 5 g of 4-chloro-2-[-3-[(1,1-dimethylethylamino]-2-hydroxypropoxy]-N-(1H-indol-4-)-benzamide were obtained.

5 g of the said base were dissolved in 300 ml of isopropanol and 300 ml of methanol at reflux and then 1.5 g of oxalic acid were added and heating was maintained for 15 minutes. After partially concentrating, cooling, filtering and drying under reduced pressure at 80° C., 4.4 g of the oxalate melting at 254° C. were obtained.

    ______________________________________                                         Analysis: C.sub.22 H.sub.26 N.sub.3 ClO.sub.3, 1/2 C.sub.2 H.sub.2             O.sub.4 : molecular weight = 460,941                                           ______________________________________                                         Calculated:                                                                             % C 59.93 % H 5.90 % N 9.12                                                                               % Cl 7.69                                  Found:   59.9      6.1      8.9     7.6                                        ______________________________________                                    

EXAMPLE 25 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-N-)1H-indol-4-yl) -5-methoxy-benzamide STEP A 4-methoxy-2[N-(1H-indol-4-yl)amido]phenol

Under an inert atmosphere, 3.96 of 4-amino indole in 70 ml of tetrahydrofuran were refluxed with 5 g of 5-methoxy-salicylic acid and 6.18 g of dicyclohexylcarbodiimide. A further 618 mg of dicyclohexycarbodiimide were added and stirring was continued at ambient temperature for 20 hours. After filtering, the solvent was eliminated under reduced pressure at 50° C. and the residue was taken up in 300 ml of ethyl acetate. The organic phase was washed with 2N hydrochloric acid, then with a saturated aqueous solution of sodium chloride, dried, and the solvent was evaporated under reduced pressure at 50° C. to obtain 9.4 g of crude product. It was purified by chromatography over silica (eluent: chloroform - ethyl acetate, 9-1), was triturated in isopropyl ether, filtered and dried to obtain 4.7 g of 4-methoxy-2-[N-(1H-indol-4-yl)amido]phenol melting at 225° C.

STEP B 5-methoxy-2-[(2-oxiranyl)methoxy]-N-(1H-indol-4-yl)-benzamide

Under an inert atmosphere, 4.5 g of 4-methoxy-2-[N-(1H-indol -4-yl)-amido]phenol in 150 ml of acetone was heated to reflux for 20 hours with 2.2 g of potassium carbonate and 12.5 ml of epichlorhydrine. The potassium carbonate was filtered off, the solvent was expelled under reduced pressure at 50° C., and the residue was chromatographed over silica (eluent: chloroform - ethyl acetate, 9-1). 5.4 g of product were collected which was triturated in ether, filtered and dried under reduced pressure to obtain 5 g of the expected product. m.p.=122° C.

STEP C 2-[3-[(1,1-dimethyl ethyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)-5-methoxy-benzamide

By operating as in Step C of Example 24, using 5 g of the product from Step B above at the start, 4.9 g of the expected product were obtained.

By operating as in Step C of Example 24 at the start from 4.9 g of the base obtained above, 3.2 g of the oxalate were obtained. m.p.=254° C.

    ______________________________________                                         Analysis: C.sub.23 H.sub.29 N.sub.3 O.sub.4, 1/2 C.sub.2 H.sub.2 O.sub.4       : molecular weight = 456.523                                                   ______________________________________                                         Calculated:                                                                               % C 63.14 % H 6.62   % N 9.20                                       Found:     62.9      6.7        9.0                                            ______________________________________                                    

EXAMPLE 26 2-[3-(cyclohexylmethyl)amino]-2-hydroxypropoxyl]-N-(1H-indol-4-yl) -benzamide

A solution of 2.5 g of 2-[(2-oxiranyl)methoxy]-N-(1H-indol -4-yl)-benzamide in 50 ml of ethanol in the presence of 1.147 g of cyclohexane methylamine was refluxed for 2 hours and 15 minutes and the solvent was evaporated under reduced pressure. The residue was chromatographed over silica (eluent: methylene chloride - methanol, 9-1) to obtain 1.97 g of 2-[3-(cyclohexylmethyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)-benzamide.

    ______________________________________                                         U.V. Spectrum (ethanol):                                                       ______________________________________                                         Infl. at 215 nm E.sub.1.sup.1 = 385                                            Infl. at 234 nm E.sub.1.sup.1 = 365                                            Infl. at 269 nm E.sub.1.sup.1 = 128                                            Infl. at 292 nm E.sub.1.sup.1 = 229                                            Max. at 297 nm  E.sub.1.sup.1 = 237                                                                      ε = 10,000                                   Infl. at 310 nm E.sub.1.sup.1 = 211                                            ______________________________________                                    

EXAMPLE 27 2-[3[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)-benzamide

Under an inert atmosphere, a solution of 0.2 g of 2[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl) -benzamide in 5 ml of methanol in the presence of 0.1 ml of formaldehyde with 40% of water was admixed with a solution of 26 mg of sodium cyanoborohydride and 27.2 mg of zinc chloride in 5 ml of methanol and the reaction mixture was left for 2 hours at ambient temperature. 5 ml of 0.1N sodium hydroxide were added, and the mixture was extracted with ethyl acetate. The organic phase was washed with water, dried, and the solvents were eliminated under reduced pressure to obtain 0.230 g of crude product. It was purified by chromatography over silica (eluent: chloroform - ethyl acetate - triethylamine, 6-3-1) to obtain 0.150 g of 2-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)-benzamide

    ______________________________________                                         U.V. Spectrum (ethanol):                                                       ______________________________________                                         Infl. at 218 nm E.sub.1.sup.1 = 794                                            Infl. at 230 nm E.sub.1.sup.1 = 429                                            Max. at 286 nm  E.sub.1.sup.1 = 181                                            Max. at 298 nm  E.sub.1.sup.1 = 176                                                                      ε = 8,850                                    Infl. at 310 nm E.sub.1.sup.1 = 158                                            Infl. at 318 nm E.sub.1.sup.1 = 147                                            ______________________________________                                    

EXAMPLE 28 2-[3-[(1,1-dimethylpropyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl) benzamide and its neutral oxalate STEP A 2-hydroxy-N-(1H-indol-4-yl)benzamide

92 ml of a solution of 1.1 mol/l of triisobutylaluminum in toluene were added slowly with stirring under an inert atmosphere to a solution of 6.6 g of 4-aminoindole in 250 ml of chloroform. 9.6 ml of methyl salicylate were then added and the mixture was refluxed for 20 hours and then cooled to room temperature. 300 ml of N hydrochloric acid and 300 ml of methylene chloride were added and the organic phase was washed with water, dried, and evaporated to dryness under reduced pressure at 50° C. The residue was made into a paste with ether, filtered and dried at 60° C. under reduced pressure to obtain 9.4 g of 2-hydroxy-N-(1H-indol-4-yl)benzamide melting at ≃232° C.

    ______________________________________                                         UV Spectrum (ethanol):                                                         ______________________________________                                         Infl. 216 nm   E.sub.1.sup.1 =                                                                        1,595                                                   Infl. 233 nm   E.sub.1.sup.1 =                                                                          680  ε                                                                            = 17,200                                   Infl. 262 nm   E.sub.1.sup.1 =                                                                          187                                                   Infl. 303 nm   E.sub.1.sup.1 =                                                                          482  ε                                                                             .sup. 12,200                              Infl. 314 nm   E.sub.1.sup.1 =                                                                          494  ε                                                                            = 12,500                                   ______________________________________                                    

STEP B 2-[(2-Oxiranyl)methoxy]-N-(1H-indol-4-yl)benzamide

A solution of 3.5 g of 2-hydroxy-N-(1H-indol-4-yl)benzamide and 1.9 g of potassium carbonate in 100 ml of acetone was refluxed for 30 hours under an inert atmosphere with 11 ml of epichlorohydrin and the insoluble material was filtered off. The filtrate was evaporated to dryness and the residue was purified by chromatography over silica (eluent: chloroform/acetone/TEA 6:3:1). Fractions having a Rf=0.45 were evaporated to dryness and the residue was empasted with ether, filtered and dried under reduced pressure at 60° C. to obtain 3.65 g of 2-[(2-oxiranyl)methoxy]-N-(1H-indol-4-yl)benzamide melting at 171° C.

STEP C 2-[3-[(1,1-dimethylpropyl)amino]-2-hydroxypropoxy) -N-(1H-indol-4-yl)benzamide

3.5 g of the product of Step B dissolved in 35 ml of ethanol was refluxed with stirring and under an inert atmosphere for 5 hours with 3 ml of tert-pentyl-amine and the solvent was evaporated off. The residue was purified by chromatography over silica (eluant: methylene chloride/methanol 9:1) to obtain 3.5 g of 2-[3-[1,1-dimethylpropyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)benzamide.

Formation of the neutral oxalate

2.4 g of the said base were dissolved in 20 ml of ethanol and 0.245 g of dehydrated oxalic acid were added. The salt formed was filtered off, dried and crystallized from ethanol to obtain 1.83 g of the expected oxalate melting at 180° C.

EXAMPLE 29 2-[3-(4-Morpholinyl)-2-hydroxypropoxy]-N-(1H-indol-4-yl)benzamide

Using the procedure of Step C of Example 28, 4 g of the product of Step B of Example 28 and 1.7 ml of morpholine were reacted to obtain 4.12 g of 2-[3-(4-morpholinyl)-2-hydroxypropoxy]-N-(1H-indol-4-yl) benzamide after chromatography over silica (eluant: chloroform/ethyl acetate/triethylamine 6:3:1).

The hydrochloride was prepared with a saturated solution of hydrochloric acid in methylene chloride and the hydrochloride, after crystallization from ethanol, melted at 210° C.

EXAMPLE 30 2-[3-[(1,1-dimethylpropyl)amino]-propoxy]-N-(1H-indol-4-yl)benzamide STEP A 2-(3-Chloropropoxy)-N-(1H-indol-4-yl)benzamide

A solution of 5 g of 2-hydroxy-N-(1-H-indol-4-yl)-benzamide, 400 ml of tetrahydrofuran, 1.8 ml of 3-chloropropanol and 5.7 g of triphenylphosphine was prepared with stirring and under an inert atmosphere and 3.4 ml of ethyl azodicarboxylate were added slowly. The mixture stood for 5 hours with stirring and 5.7 g of triphenylphosphine and 1.8 ml of 3-chloropropanol were added, followed by 3.4 ml of ethyl azodicarboxylate added slowly. The mixture stood again with stirring for 15 hours and was evaporated to dryness. The residue was purified by chromatography over silica (eluant: benzene/ethyl acetate 95:5) and the fractions having a Rf=0.15 were evaporated to dryness. The residue was empasted with ether, filtered and dried under reduced pressure to obtain 5.5 g of 2-(3-chloropropoxy)-N-(1H-indol-4-yl)benzamide melting at 140° C.

STEP B 2-[3-[(1,1-dimethylpropyl)amino]-propoxy)-N-(1H-indol-4-yl) benzamide

2 g of the product of Step A in 20 ml of ethanol were heated to 120° C. for 5 hours with 2 ml of tert-pentylamine and in the presence of 0.84 g of potassium carbonate, the mixture was filtered. The solvent was evaporated off and the residue was purified by chromatography on silica (eluant: methylene chloride/methanol 9:1) to obtain 2 g of 2-[3-[(1,1-dimethylpropyl) amino]-propoxy)-N-(1H-indol-4-yl)benzamide.

Hydrochloride

1.45 g of the base were dissolved in 20 ml of isopropanol at 50° C. and a saturated solution of hydrochloric acid in ethyl acetate was added until the pH was acid. The mixture was chilled, filtered and dried and the product was crystallized from isopropanol to obtain 1.7 g of the expected hydrochloride melting at 216° C.

EXAMPLE 31 2-[3-(Cyclohexylamino)propoxy]-N-(1-H-indol-4-yl)benzamide

Using the procedure of Example 30 replacing tert-pentylamine by cyclohexylamine and chromatography on silica (eluant: CHCl₃ /ethyl acetate/TEA 6:3:1), 2.1 g of 2-[3-(cyclohexylamino)propoxy]-N-(1H-indol-4-yl)benzamide melting at 148° C. were obtained, and the hydrochloride which melted at 214° C. after crystallization from isopropanol was then formed.

EXAMPLE 32 2-[3-[Cyclohexylmethylamino]-propoxy)-N-(1H-indol-4-yl)benzamide

Using the procedure of Example 30, but replacing tert-pentylamine with cyclohexylmethylamine, 2-[3-[cyclohexylaethylamino]propoxy)-N-(1H-indol -4-yl)benzamide was obtained, and then its hydrochloride which was crystallized from ethanol melting at 228° C.

EXAMPLE 33 2[4-[1,1-Dimethylethylamino]butoxy]-N-(1H-indol-4-yl)benzamide

Using the procedure of Example 30 but at 50° C. and replacing tert-pentylamine by tert-butylamine and 2-(3-chloropropoxy)-N-1H-indol-4-yl)benzamide by 2-(4-bromobutoxy)-N-(1H-indol4-yl)benzamide, and with chromatography on silica (eluant: CHCl₃ /acetone/TEA of 6:3:1), the residue was taken up in ether to obtain 2-[4-[1,1-dimethylethylamino]-butoxy]-N-(1H-indol-4-yl)benzamide melting at 147° C. The acid fumarate, which melted at 224°-225° C. with sublimation after crystallization from ethanol, was prepared.

Preparation of 2-(4-bromobutoxy)-N-(1H-indol-4-yl)benzamide

A suspension of 7.5 g of 2-hydroxy-N-(1H-indol-4-yl)benzamide and 8.28 g of potassium carbonate in 150 ml of acetone was refluxed for 75 minutes with 18 ml of 1,4-dibromobutane and the mixture was cooled. The precipitate was filtered off and rinsed with acetone and the filtrate was evaporated to dryness. The residue was purified by chromatography over silica (eluant: methylene chloride/ethyl acetate 9:1), followed by crystallization from ethyl acetate to obtain 2-(4-bromobutoxy) -N-(1H-indol-4-yl)benzamide melting at 135° C.

EXAMPLE 34 2-[3-[1,1-Dimethylethylamino]-2-hydroxypropoxy]-N-(1-methyl-1H-indol-4-yl) benzamide STEP A 2-[(2-Oxiranyl)methoxy]-N-(1-methyl-1H-indol-4-yl)-benzamide

Using the procedure of Example 28, Step A, 2-hydroxy-N-(1-methyl -1H-indol-4-yl)-benzamide was reacted to obtain 2-[2-Oxiranyl)methoxy]-N-(1-methyl-1H-indol-4-yl)benzamide melting at 160° C.

STEP B

Using the procedure of Example 28, Step B, the product of Step A and replacing tert-pentylamine by tert-butylamine were reacted to obtain 2-[(2-oxiranyl)methoxy]-N-(1-methyl-H-indol-4-yl)-benzamide melting at 130° C. and the hydrochloride, which melted at 195° C. after crystallization from isopropanol, was prepared.

Preparation of 2-hydroxy-N-(1-methyl-1H-indol-4-yl)benzamide

A solution of 5 g of 1-methyl-1H-indol-4-amine [prepared according to Ley (J. Chem. Soc. Chem. Com. (1982) p. 1356], 4.7 g of salicylic acid and 7 g of dicyclohexylcarbodiimide in 80 ml of tetrahydrofuran was refluxed for 24 hours and 20% of salicylic acid and of dicyclohexylcarbodiimide were added after 5 hours of refluxing. The mixture was filtered and the filtrate was evaporated under reduced pressure. The residue was purified by chromatography over silica (eluant: methylene chloride) to obtain 5.5 g of 2-hydroxy-N-(1-methyl-1H-indol-4-yl)benzamide melting at 211° C.

EXAMPLE 35 2-[3-[1,1-Dimethyl-2-propynylamino]-2-hydroxypropoxy]-N-(1H-indol-4-yl) benzamide

Using the procedure of Step C of Example 28, 4 g of the product of Step B of Example 1 and 1.5 ml of 1,1-dimethylpropargylamine were reacted to obtain 3.77 g of 2-[3-[1,1-dimethyl-2-propynylamino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)benzamide after chromatography on silica (eluant: chloroform/ethyl acetate/triethylamine 6:3:1).

Neutral oxalate

3.09 g of the said product were dissolved in 100 ml of ethanol and 0.497 g of oxalic acid were added. The mixture was chilled, filtered and dried under reduced pressure at 80° C. The product was crystallized from ethanol to obtain 2.5 g of the neutral oxalate melting at 160° C.

    ______________________________________                                         Analysis: C.sub.23 H.sub.25 N.sub.3 O.sub.3 ; molecular weight                 ______________________________________                                         = 872.984                                                                      Calculated:                                                                             % C    66.04    % H  6.00   % N  9.63                                 Found:          65.9          6.0         9.5                                  ______________________________________                                    

EXAMPLE 36 2-[2-Hydroxy-3-[1,1,3,3-tetramethylbutyl-amino]propoxy]-N-(1H-indol-4-yl)benzamide

Using the procedure of Example 28, Step C, 5 g of the product of Step B of Example 28 and 4.9 ml of tert-octylamine were reacted to obtain 4.27 g of 2-[2-Hydroxy-3-[1,1,3,3-tetramethylbutyl-amino]propoxy]-N-(1H-indol -4-yl)benzamide melting at 140° C.

    ______________________________________                                         Analysis: C.sub.26 H.sub.35 N.sub.3 O.sub.3 ; molecular weight                 ______________________________________                                         = 437.587                                                                      Calculated:                                                                               % C 71.37 % H 8.06   % N 9.60                                       Found:     71.6      8.3        9.5                                            ______________________________________                                    

EXAMPLE 37 2-[3-[1,1-Dimethyl-2-hydroxyethylamino]-2-hydroxypropoxy]-N-(1H-indol -4-yl)benzamide

Using the procedure of Example 28, Step C, 4 g of the product of Step B of Example 28 and 1.3 ml of 2-amino-2-methyl-1-propanol were reacted to obtain 3.33 g of 2-[3-[1,1-dimethyl-2-hydroxyethylamino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)benzamide and it was converted to the neutral oxalate as described in Example 35. 2.8 g of expected oxalate was obtained melting at 180° C.

    ______________________________________                                         Analysis: C.sub.22 H.sub.27 N.sub.3 O.sub.4 ; molecular weight                 ______________________________________                                         = 884.99                                                                       Calculated:                                                                               % C 62.43 % H 6.38   % N 9.50                                       Found:     62.3      6.6        9.4                                            ______________________________________                                    

EXAMPLE 38 N-(1H-Indol-4-yl)-2-[3-(propylamino)propoxy]-benzamide

Using the procedure of Step B of Example 30, 4.5 g of the product of Step A of Example 30 and 6.5 ml of N-propylamine were reacted to obtain after chromatography over silica (eluant: chloroform/ethyl acetate/triethylamine 6:3:1), 3.20 g of N-(1H-indol-4-yl)-2-[3-(propylamino)propoxy]-benzamide. 3 g of the base were converted to the hydrochloride as described in Example 30 to obtain 2 g of hydrochloride melting at 202° C.

    ______________________________________                                         Analysis: C.sub.21 H.sub.25 N.sub.3 O.sub.2 ; molecular weight                 ______________________________________                                         = 387.913                                                                      Calculated:                                                                             % C 65.02 % H 6.76 % Cl 9.14                                                                               % N 10.83                                 Found:   64.9      6.7      9.3      10.7                                      ______________________________________                                    

EXAMPLE 39 N-(1H-Indol-4-yl)-2-[3-(1-methylethyl)amino]-propoxy]benzamide

Using the procedure of Example 38, 4 g of starting substance and 10 ml of isopropylamine were reacted to obtain 2.93 g of N-(1H-indol -4-yl)-2-[3-(1-methylethyl)amino]-propoxy]benzamide and 1.79 g of its hydrochloride from 2.6 g of base which melted at 180° C.

    ______________________________________                                         Analysis: C.sub.21 H.sub.25 N.sub.3 O.sub.2 ; molecular weight                 ______________________________________                                         = 387.913                                                                      Calculated:                                                                             % C 65.02 % H 6.76 % Cl 9.14                                                                               % N 10.83                                 Found:   65.0      6.9      9.0      10.8                                      ______________________________________                                    

EXAMPLE 40 2-[3-[1,1-Dimethyl-2-hydroxyethylamino]-propoxy]-N-indol-4-yl)benzamide

Using the procedure of Example 30 Step B, 3 g of product of Step A of Example 30 and 5 ml of 2-amino-2-methyl-1-propanol were reacted to obtain after chromatography over silica (eluant: chloroform/methanol/triethylamine 90:5:5), 2.1 g of 2-[3-[1,1-dimethyl-2-hydroxyethylamino]-propoxy]-N-(1H-indol-4-yl)benzamide.

Neutral fumarate

Using 1.85 of the said base and 5.63 g of fumaric acid, 1.323 g of the neutral fumarate melting at 186° C. were obtained.

    ______________________________________                                         Analysis: (C.sub.22 H.sub.27 N.sub.3 O.sub.3).sub.2.C.sub.4 H.sub.4            O.sub.4 ; molecular weight = 879.031                                           ______________________________________                                         Calculated:                                                                               % C 65.59 % H 6.65   % N 9.56                                       Found:     65.5      6.9        9.3                                            ______________________________________                                    

EXAMPLE 41 N-[2-[3-[Isopropylamino]propoxy]phenyl]-1H-indole-4-carboxamide STEP A N-[2-(3-(Bromopropoxy)phenyl]-1H-indole-4-carboxamide

A suspension of 2 g of N-(2-hydroxyphenyl)-1H-indol-4-carboxamide and 2.18 g of potassium carbonate in 20 ml of acetone was admixed with 3.2 ml of 1,3-dibromopropane and the mixture was refluxed for 90 minutes and was filtered. The solvent was evaporated under reduced pressure and the residue was chromatographed over silica (eluant: chloroform/ethyl acetate/triethylamine 6:3:1 to obtain 2.37 g of N-[2-[3-bromopropoxyl]phenyl]-1H-indole-4-carboxamide melting at 145° C.

STEP B N-[2-[3-[(1-Methylethyl)amino]propoxy]phenyl]-1H-indole-4-carboxide

Using the procedure of Step B of Example 30, 4 g of product of Step A and 4.5 ml of isopropylamine were reacted to obtain after chromatography silical (eluant: chloroform/ethyl acetate/triethylamine over 6:3:1), 2.91 g of N-[2-[3-[(1-methylethyl)amino]propoxy]phenyl]-1H-indole-4-carboxide, and then 2.5 g of its hydrochloride melting at 234° C.

    ______________________________________                                         Analysis: C.sub.21 H.sub.25 N.sub.3 O.sub.2.HCl                                ______________________________________                                         Calculated:                                                                             % C 65.02 % H 6.76 % Cl 9.14                                                                               % N 10.83                                 Found:   65.3      6.8      9.3      10.7                                      ______________________________________                                    

EXAMPLE 42 N-[2-[3-(Cyclopentylamino)propoxy]phenyl]-1H-indol-4-carboxamide

Using the procedure of Example 41, Step B, 4 g of the product of Step of A of Example 41 and 2.11 ml of cyclopentylamine were reacted to obtain 3.3 g of N-[2-[3-(cyclopentylamino)propoxy]phenyl]-1H-indol-4-carboxamide and then 2.8 g of its hydrochloride melting at 244° C.

    ______________________________________                                         Analysis: C.sub.21 H.sub.27 N.sub.3 O.sub.2.HCl; molecular weight =            ______________________________________                                         413.95                                                                         Calculated:                                                                             % C 66.74 % H 6.82 % Cl 8.56                                                                               % N 10.15                                 Found:   66.9      6.8      8.4      9.9                                       ______________________________________                                    

EXAMPLE 43 N-[2-[3-(Cyclohexylamino)propoxy]phenyl]-1H-indole-4-carboxamide

Using the procedure of Example 41, Step B, 2.5 g of the product of Step B of Example 41 and 1.5 ml of cyclohexylamine were reacted to obtain 1.8 g of N-[2-[3-(cyclohexylamino)propoxy]phenyl]-1H-indole-4-carboxamide and 1.7 g of its hydrochloride melting at 260° C.

    ______________________________________                                         Analysis: C.sub.24 H.sub.29 N.sub.3 O.sub.2.HCl; molecular weight =            427.979                                                                        ______________________________________                                         Calculated:                                                                             % C 67.35 % H 7.06 % Cl 8.28                                                                               % N 9.82                                  Found:   67.1      7.1      8.4      9.7                                       ______________________________________                                    

EXAMPLE 44 N-[2-[3-[1,1-Dimethylpropylamino]propoxy]phenyl]-1H-indole-4-carboxamide

Using the procedure of Example 41, Step B, 4 g of the compound of Step B of Example 41 and 5 ml of tert-amylamine were reacted to obtain 2.90 g of N-[2-[3-[1,1-dimethylpropylamino]propoxy]phenyl]-1H-indole-4-carboxamide and then 2.5 g of its hydrochloride from 2.7 g of base melting at 230° C.

    ______________________________________                                         Analysis: C.sub.23 H.sub.29 N.sub.3 O.sub.2.HCl; molecular weight =            415.967                                                                        ______________________________________                                         Calculated:                                                                             % C 66.41 % H 7.27 % Cl 8.52                                                                               % N 10.1                                  Found:   66.4      7.3      8.6      10.1                                      ______________________________________                                    

EXAMPLE 45 N-[2-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]-amino]propoxy]phenoxy]-1H-indole-4-carboxamide

Using the procedure of Example 41, Step B, 3 g of the compound of Step B of Example 14 and 2.31 ml of homoveratrylamine to obtain after chromatography over silica (eluant: chloroform/methanol 9:1), 2.75 g of N-[2-[3-[[2-(3,4-dimethoxyphenyl)ethyl]-amino]propoxy]phenyl]-1H-indole-4-carboxamide and then 1.75 g of its hydrochloride from 2.55 g of base melting at 182° C.

    ______________________________________                                         Analysis: C.sub.20 H.sub.31 N.sub.3 O.sub.4.HCl; molecular weight =            510.038                                                                        ______________________________________                                         Calculated:                                                                             % C 65.94 % H 6.32 % Cl 6.95                                                                               % N 8.24                                  Found:   65.9      6.2      6.7      8.2                                       ______________________________________                                    

EXAMPLE 46 2-[2-Hydroxy-3-[4-(diphenylmethyl)-1-piperazinyl]propoxy]-N-(1H-indol-4-yl)benzamide

Using the procedure of Example 28 of Step C, 3.08 g of 2-[(2-oxiranyl)methoxy]-N-(1H-indol-4-yl)benzamide of Step B of Example 28, and 5.2 g of 1-(diphenylmethyl)piperazine were reacted to obtain after chromatography over silica (eluant: chloroform/ethyl acetate 7:3), 5.12 g of 2-[2-hydroxy-3-[4-(diphenylmethyl)-1-piperazinyl]propoxy]-N-(1H-indol-4-yl)benzamide, and then 3.22 g of its neutral oxalate from 4.36 g of base melting at 170° C.

    ______________________________________                                         Analysis: (C.sub.35 H.sub.36 N.sub.4 O.sub.3).sub.2.C.sub.2 H.sub.2            O.sub.4 ; molecular weight = 1211.44                                           ______________________________________                                         Calculated:                                                                               % C 71.38 % H 6.15   % N 9.24                                       Found:     71.4      6.3        9.1                                            ______________________________________                                    

EXAMPLE 47 N-(1H-Indol-4-yl)-2-[4-[4-[2-(3,4,5-trimethoxyphenyl)ethyl]-1-piperazinyl]butoxy]benzamide

2.5 g of 2-(4-bromobutyoxy)-N-(1H-indol-4-yl)benzamide of Example 33, 2.71 g of 1-[2-(3,4,5-trimethoxyphenyl)ethyl]piperazine [German Patent No. 3,347,173] and 0.683 g of sodium carbonate in 25 ml of ethanol were heated to 60° C. for 10 hours and the mixture is cooled and poured into water and extracted with ethyl acetate. The extract was washed with water and dried and the solvents were evaporated under reduced pressure. The residue was chromatographed over silica (eluant: chloroform/acetone/triethylamine 6:3:1) to obtain 3.51 g of N-(1H-indol-4-yl)-2-[4-[4-[2-(3,4,5-trimethoxyphenyl)ethyl]-1-piperazinyl]butoxy]benzamide.

Difumarate

Using 2.52 g of the said base and 498 mg of fumaric acid, 1.718 g of its difumarate melting at 183° C. were obtained.

    ______________________________________                                         Analysis: C.sub.34 H.sub.42 N.sub.4 O.sub.5).sub.2.C.sub.8 H.sub.8             O.sub.8 ; molecular weight = 818.895                                           ______________________________________                                         Calculated:                                                                              % C 61.60     % H 6.15 % N 6.84                                      Found:    61.3          6.1      6.6                                           ______________________________________                                    

EXAMPLE 48 2-[3-[(1,1-Dimethylpropyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)benzamide benzoate

1.11 g of benzoic acid were added to a solution of 3.6 g of the free base of Step C of Example 28 and the mixture was chilled, filtered and dried under reduced pressure at 90° C. to obtain 3 g of 2-[3-[(1,1-dimethylpropyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)benzamide benzoate after crystallization from isopropanol melting at 170° C.

    ______________________________________                                         Analysis: C.sub.23 H.sub.29 N.sub.3 O.sub.3 ; molecular weight                 ______________________________________                                         = 517.615                                                                      Calculated:                                                                              % C 69.91     % H 6.82 % N 8.12                                      Found:    69.9          6.8      8.2                                           ______________________________________                                    

EXAMPLE 49 2-[2-Hydroxy-3-[4-diphenylmethyl)-1-piperazinyl]propoxy]-N-(1-methyl-1H-indol-4-yl)benzamide

Using the procedure of Example 28, of Step C, 4 g of 2-[(2-oxiranyl)methoxy]-N-(1-methyl-1H-indol-4-yl)benzamide of Example 34 and and 6.3 g of diphenylmethylpiperazine were reacted to obtain 5.95 of 2-[2-hydroxy-3-[4-(diphenylmethyl)-1-piperazinyl]propoxy]-N-(1-methyl-1H-indol-4-yl)benzamide and then 4.9 g of its hydrochloride melting at 196° C. after crystallization from ethanol.

    ______________________________________                                         Analysis: C.sub.36 H.sub.38 N.sub.4 O.sub.3.HCl; molecular weight =            ______________________________________                                         611.19                                                                         Calculated:                                                                            % C 70.76 % H 6.43  % Cl 5.80                                                                               % N 9.17                                  Found   70.4      6.3       5.9      9.1                                       ______________________________________                                    

Using the procedure of already described in the examples, also prepared the following product to 2-[2-hydroxy-3-[[4-bis(4-fluoro-benzyl]-1-piperazinyl]propoxy]phenyl]-N-(1H-indol-4-yl)benzamide.

EXAMPLE 50 2-[3-(1,1-Dimethylethyl)-amino]-2-hydroxy-propoxy]-N-(1H-indol-4-yl)-5-nitro-benzamide STEP A 2-Hydroxy-5-nitro-N-(1H-indol-4-yl)-benzamide

A mixture of 6 g of 4-amino-indole, 150 ml of tetrahydrofuran, 8.4 g of 5-nitro-salicylic acid and 12.5 g of dicyclohexylcarbodiimide was refluxed for 3 hours and cooled and filtered. 200 ml of ethyl acetate were added to the filtrate and excess 4-amino-indole was removed by washing with 1N hydrochloric acid. The mixture was dried and filtered and the filtrate was evaporated to dryness under reduced pressure at 50° C. to obtain 20 g of a resin. The latter was empasted with a 1-1 mixture of chloroform and methanol and filtered. The filtrate was evaporated to dryness under reduced pressure to obtain 7.5 g of 2-hydroxy-5-nitro-N-(1H-indol-4-yl)-benzamide melting at >260° C.

STEP B 2-[3-(1,1-dimethylethyl)amino]-2-hydroxy-propoxy-N-(1H-indol-4-yl)-5-nitro-benzamide

A mixture of 9.8 g of the product of Step A and 40 ml of epibromohydrin was refluxed for one hour and excess epibromohydrin was removed under reduced pressure at 60° C. The resulting resin was taken up in 100 ml of ethanol and 40 ml of tert.-butylamino and the mixture was refluxed for 2 hours. The mixture was evaporated to dryness under reduced pressure at 60° C. to obtain 78 g of raw product. The latter was chromatographed twice with successive elutions with fast chloroform-methanol-triethylamine (8-1-1) and then chloroform-acetone-triethylamine (5-4-1) to obtain 4.4 g of 2-[3-(1,1-dimethylethyl)amino]-2-hydroxy-propoxy-N-(1H-indol-4-yl)-5-nitro-benzamide melting at 208° C.

A solution of 3.5 g of the said product in one liter of isopropanol and 250 ml of methanol was refluxed and a saturated solution of ethyl acetate saturated hydrogen chloride was added until the pH was acidic. The mixture was refluxed for 30 minutes and was concentrated to about 500 ml, iced and filtered. The product was dried under reduced pressure at 50° C. to obtain 2.85 g of the hydrochloride melting at >260° C.

    ______________________________________                                         Analysis:                                                                      ______________________________________                                         Calculated:                                                                            % C 57.08 % H 5.88  % N 12.10                                                                              % Cl 7.66                                  Found:  56.8      6.1       12.0    7.4                                        ______________________________________                                    

EXAMPLE 51 5-Amino-2-[3-(1,1-dimethylethyl)amino]-2-hydroxy-propoxy-N-(1H-indol-4-yl)-benzamide

A mixture of 142 mg of the product of Example 50, 5 ml of methanol, a pinch of Raney nickel and 0.2 ml of hydrazine hydrate was refluxed for one hour and was then filtered. The filtrate was evaporated to dryness under reduced pressure at 50° C. to obtain 128 mg of 5-amino-2-[3-(1,1-dimethylethyl)amino]-2-hydroxy-propoxy-N-(1H-indol-4-yl)-benzamide.

    ______________________________________                                         U.V. Spectrum (ethanol):                                                       Max. at 219 nm     E.sup.1 .sub.1 = 433                                        Max. at 310 nm     E.sup.1 .sub.1 = 230                                        U.V. Spectrum (ethanol-N HCl):                                                 Max. at 299 nm     E.sup.1 .sub.1 = 208                                                                       ε = 8,200                               Inflex towards 275 and 332 mm                                                  ______________________________________                                    

EXAMPLE 52 5-Acetylamino-2-[3-(1,1-dimethylethyl)-amino]-2-hydroxy-propoxy-N-(1H-indol-4-yl)-benzamide STEP A 5-Amino-2-hydroxy-N-(1H-indol-4-yl)-benzamide

A suspension of 6 g of 5-nitro-2-hydroxy-N-(1H-indol-4-yl)-benzamide of Example 50, 600 ml of methanol and 15 ml of 64% hydrazine hydrate and 6 g of Raney nickel was refluxed for two hours and filtered. The filtrate was evaporated to dryness under pressure at 50° C. and the residue was taken up in a 1-1 mixture of chloroform and methanol. The mixture was filtered and the crystalline product was dried to obtain 4 g of 5-amino-2-hydroxy-N-(1H-indol-4-yl)-benzamide melting at >260° C.

STEP B 5-Acetylamino-2-acetoxy-N-(1H-indol-4-yl)-benzamide

A suspension of 2.6 g of the produce of Step A in 70 ml of tetrahydrofuran was cooled to 0° to 5° C. and then 4.7 ml of acetic anhydride were added. The mixture was held at room temperature for 3 hours and was then evaporated to dryness under reduced pressure at 50° C. The residue was taken up in a 1-1 mixture of chloroform-methanol and was filtered. The produce was dried at 80° C. to obtain 2.7 g of 5-acetylamino-2-acetoxy-N-(1H-indol-4-yl)-benzamide melting at 263° C.

STEP C 5-Acetylamino-2-hydroxy-N-(1H-indol-4-yl)-benzamide

1.5 g of boron hydride and sodium were added to a suspension of 1.5 g of the product of Step B in 150 ml of methanol and the mixture was refluxed for 2 hours. The methanol was partially removed under reduced pressure at 50° C. and the mixture was diluted with 200 ml of water and 200 ml of ethyl acetate. The mixture was extracted with ethyl acetate and the extracts were dried and evaporated to dryness under reduced pressure at 50° C. to obtain 1.35 g of 5-acetylamino-2-hydroxy-N-(1H-indol-4-yl)-benzamide which was used as is for the next step.

STEP D 5-Acetylamino-2-(2-oxiranyl)-methoxy]-N-(1H-indol-4-yl)-benzamide

A mixture of 3.5 g of the product of Step C, 150 ml of acetone, 1.5 g of potassium carbonate and 9 ml of epibromohydrin was refluxed for 2 hours and after the addition of another 9 ml of epibromohydrin, the mixture was refluxed for 20 hours and was filtered. The filtrate was washed with acetone and evaporated to dryness under reduced pressure at 50° C. The residue was taken up in ether and was filtered. The product was dried at 80° C. to obtain 3.4 g of 5-acetylamino-2-[(2-oxiranyl)-methoxy]-N-(1H-indol-4-yl)-benzamide melting at 230° C.

STEP E 5-Acetylamino-2-[3-(1,1-dimethylethyl)-amino]-2-hydroxy-propoxy-N-(1H-indol-4-yl)-benzamide

A mixture of 3.4 g of the produce of Step D, 200 ml of ethanol and 20 ml of tert.-butylamine was refluxed for one hour and was then evaporated to dryness under reduced pressure at 50° C. The residue was chromatographed over silica and was eluted with a 8-1-1 chloroform-methanol-triethylamine mixture to obtain 3.8 g of 5-acetylamino-2-[3-(1,1-dimethylethyl)-amino]-2-hydroxy-propoxy-N-(1H-indol-4-yl)-benzamide

2.7 g of the said compound were dissolved in 200 ml of ethanol and 330 g of oxalic acid were added thereto. The mixture was filtered and the product was dried under reduced pressure at 80° C. to obtain 2.2 g of the neutral oxalate melting at >260° C.

    ______________________________________                                         Analysis: C.sub.24 H.sub.30 N.sub.4 O.sub.4. 1/2 C.sub.2 H.sub.2 O.sub.4       ; molecular weight = 423.549                                                   ______________________________________                                         Calculated:                                                                              % C 62.10    % H 6.46 % N 11.59                                      Found:    61.9         6.2      11.5                                           ______________________________________                                    

EXAMPLE 53 2-[3-(1,1-dimethylethyl)-amine]-2-hydroxy-propoxy-N-(1H-indol-4-yl)-4-methoxy-benzamide STEP A 4-methoxy-2-hydroxy-N-(1H-indol-4-yl)-benzamide

A mixture of 3.96 g of 4-amino-1H-indole, 70 ml of tetrahydrofuran, 5 g of 2-hydroxy-4-methoxy-benzoic acid and 6.2 g of dicyclohexycarbodiimide was refluxed for 24 hours and was evaporated to dryness under reduced pressure at 50° C. The residue was taken up in ethyl acetate and excess 4-amino-1H-indole was removed by washing with 2N hydrochloric acid. The mixture was evaporated to dryness under reduced pressure and the residue was taken up in ether and dried at 50° C. to obtain 7.1 g of 4-methoxy-2-hydroxy-N-(1H-indol-4-yl)-benzamide melting at 190° C.

STEP B 4-Methoxy-2-[(2-oxiranyl)-methoxy]-N-(1H-indol-4-yl)-benzamide

Using the procedure of Step D of Example 52, 5 g of the product of Step A, 150 ml of acetone, 2.45 g of potassium carbonate and 14 ml of epichlorohydrin were reacted to obtain 7.3 g of 4-methoxy-2-[(2-oxiranyl)-methoxy]-N-(1H-indol-4-yl)-benzamide melting at 157° C.

STEP C 2-[2-[3-(1,1-dimethylethyl)-amino]-2-hydroxy-propoxy]-N-(1H-indol-4-yl)-4-methoxy-benzamide

Using the procedure of Step E of Example 52, 6 g of the product of Step B, 100 ml of ethanol, 9.2 ml of tert.-butylamine were refluxed for 3 hours to obtain 6.1 g of 2-[2-(1,1-dimethylethyl)-amino]-2-hydroxy-propoxy]-N-(1H-indol-4-yl)-4-methoxy-benzamide. The product was dissolved in 300 ml of refluxing of isopropanol and 1.8 g of benzoic acid were added thereto. The mixture was partially concentrated, iced and filtered and the product was dried under reduced pressure to obtain 5.1 g of the benzoate salt melting at 195° C. after crystallization for ethanol.

    ______________________________________                                         Analysis: C.sub.23 H.sub.29 N.sub.3 O.sub.4 ; molecular weight                 ______________________________________                                         = 533.629                                                                      Calculated:                                                                              % C 67.53     % H 6.61 % N 7.87                                      Found:    67.5          6.7      8.0                                           ______________________________________                                    

EXAMPLE 54 5-Chloro-2-[3-(1,1-dimethylethyl)-amino]-2-hydroxy-propoxy-N-(1H-indol-4-yl)-benzamide STEP A 5-chloro-3-hydroxy-N-(1H-indol-4-yl)-benzamide

A mixture of 3.96 g of 4-amino-1H-indole, 75 ml of tetrahydrofuran, 5.16 g of 5-chloro-salicyclic acid and 6.2 g of dicyclohexylcarbodiimide was refluxed for 2 hours and after the addition of another 0.62 g of dicyclohexylcarbodiimide, the mixture was refluxed for one hour, cooled and was filtered. The filtrate was evaporated to dryness under reduced pressure at 50° C. and the residue was taken up in ethyl acetate. The solution was washed with 2N hydrochloric acid, dried and evaporated to dryness under reduced pressure at 50° C. The residue was chromatographed over silica and was eluted with a 9-1 mixture of chloroform-ethyl acetate to obtain 3.9 g of 5-chloro-3-hydroxy-N-(1H-indol-4-yl)-benzamide melting at 248° C.

STEP B 5-chloro-1-(2-oxiranyl)-methoxy]-N-(1H-indol-4-yl)-benzamide

Using the procedure of Step D of Example 52, 3 g of the product of Step A, 100 ml of acetone, 1.47 g of potassium carbonate and 8.3 ml of epichlorohydrin were reacted to obtain 3.35 g of 5-chloro-1-[(2-oxiranyl)-methoxy]-N-(1H-indol-4-yl)-benzamide melting at 175° C.

STEP C 5-chloro-2-[2-(1,1-dimethylethyl)-amino]-2-hydroxy-propoxy-N-(1H-indol-4-yl)-benzamide

Using the procedure of Step E of Example 52, 3 g of the product of Step B, 60 ml of ethanol and 4.6 ml of tert.-butylamine were reacted to obtain 2.6 g of 5-chloro-2-[3-(1,1-dimethylethyl)-amino]-2-hydroxy-propoxy-N-(1H-indol-4-yl)-benzamide and then 2.4 g of its oxalate melting at >260° C.

    ______________________________________                                         Analysis: C.sub.22 H.sub.26 ClN.sub.3 O.sub.3 ; molecular weight =             ______________________________________                                         460.941                                                                        Calculated:                                                                            % C 59.93 % H 5.90  % N 9.12                                                                               % Cl 7.69                                  Found:  60.2      5.8       9.1     7.9                                        ______________________________________                                    

EXAMPLE 55

Tablets were prepared containing 50 mg of the product of Example 50 or 50 mg of the neutral oxalate of 2-[3-(1,1-dimethylethyl)amino]-2-hydroxy-propoxy-N-(1H-indol-4-yl)-benzamide and sufficient excipient of lactose, starch, talc and magnesium stearate for a final weight of 100 mg. Tablets were also prepared containing 100 mg of 2-[3-(1,1-dimethylethyl)amino]-2-hydroxy-propoxy-(1H-indol-4-yl)-benzamide and sufficient of the said excipient for a final weight of 150 mg.

PHARMACOLOGICAL STUDY

1. Anti-arrhythmic action in the rat

Male rats weighing 300-350 g were anesthetized intra-peritoneally with 1.20 g/kg of urethane, then tracheotomized and submitted to artificial respiration (40-50 breaths of 3 ml/minute). Needles were implanted subcutaneously so as to record the electro-cardiogram of the rats on the D_(II) derivation signal. The products under test were administered intravenously or orally.

Five minutes after the administration of the product intravenously or 1 hour after administration orally, the jugular vein of the rats was perfused with 10 μg/minute from 0.2 ml of a solution of aconitine, and the time of appearance of disturbances of the cardiac rhythm was noted, (10 μg of aconitine corresponding to a perfusion of 0.2 ml of solution). The results are expressed as a percentage of the extension of the time of appearance of the disturbances of the cardiac rhythm as compared with controls, and as a function of the dose of the product under test. The results appearing in the following table show that the products of the present application are endowed with remarkable anti-arrhythmic properties.

    ______________________________________                                                              Dose in  Percentage extension                             Product of Example                                                                         Route    mg/kg    of the time                                      ______________________________________                                         1           IV       0.25     +31                                                                   0.5      +41                                                                   1        +110                                             2           IV       1        +6                                                                    2.5      +57                                              3           IV       2.5      +68                                              4           IV       0.5      +17                                                                   1.0      +38                                                                   2.5      +124                                                         PO       5        +7                                                                    10       +46                                                                   25       +81                                              5           IV       0.25     +9                                                                    0.5      +36                                                                   1        +33                                                                   2.5      +61                                                          PO       2.5      +22                                                                   5        +32                                                                   10       +59                                              6           IV       1        +23                                                                   2.5      +41                                                          PO       2.5      +29                                              15          IV       2.5      +25.5                                                                 5        +56                                              28                   1        +14                                                                   2.5      +54                                                                   5.0      +95                                              30                   2.5      +38                                                                   5        +99                                                                   10       +147                                             31                   1        +24                                                                   2.5      +34                                                                   5.0      +83                                              32                   6.5      +28                                                                   1.0      +43                                                                   2.5      +71                                                                   5.0      +97                                              ______________________________________                                         Product of       Dose in    Percentage of prolongation                         Example Route    mg/kg      in the time                                        ______________________________________                                         33               5 mg/kg    54%                                                                 10 mg/kg   99%                                                34               2.5 mg/kg  12%                                                                 5 mg/kg    43%                                                                 10 mg/kg   125%                                               36               1 mg/kg    25%                                                                 2.5 mg/kg  69%                                                37               1 mg/kg    47%                                                                 5 mg/kg    116%                                               38               2.5 mg/kg  42%                                                                 5 mg/kg    76%                                                                 10 mg/kg   173%                                               40               1 mg/kg    21%                                                                 2.5 mg/kg  50%                                                41               1 mg/kg    34%                                                                 2.5 mg/kg  57%                                                                 5 mg/kg    156%                                               42               1 mg/kg    29%                                                                 2.5 mg/kg  86%                                                43               1 mg/kg    49%                                                                 2.5 mg/kg  83%                                                44               1 mg/kg    50%                                                                 2.5 mg/kg  90%                                                                 5 mg/kg    167%                                               45               2.5 mg/kg  60%                                                                 5 mg/kg    142%                                                                10 mg/kg   193%                                               46               2.5 mg/kg  67%                                                                 5 mg/kg    127%                                                                10 mg/kg   203%                                               47               5 mg/kg    44%                                                                 10 mg/kg   67%                                                48               2.5 mg/kg  53%                                                                 5 mg/kg    79%                                                50      IV       2.5        +77%                                                                1          +39%                                                                0.5        +17%                                               53      IV       2.5        +38%                                                                1          +10%                                               ______________________________________                                    

2. Affinity for beta₁ -adrenergic receptors

The technique is modelled on that of Mohler et al [Science., Vol. 198, p. 849-851 (1977)]. 10 cortexes removed from the brains of male rats weighing 150 g on average were homogenized in 90 ml of 0.32M sucrose and after centrifugation of the homogenized mixture at 1,000 g for 20 minutes at 0° C., the supernatant was centrifuged at 30,000 g for 15 minutes at 0° to +4° C. The pellet was suspended in 120 ml of 50 mM Tris-HCl buffer pH 7.7, and centrifuged at 30,000 g for 15 minutes at 0° to +4° C. The new pellet was suspended in 480 ml of 50 mM Krebs Tris-HCl buffer pH 7.7. 2 ml of the suspension were then incubated for 10 minutes at 37° C. in the presence of [³ H] dihydroalprenolol at a concentration of 10⁻⁹ M, i) alone, ii) with increasing concentrations of the test product or iii) to determine the non-specific binding, with non-radioactive propanolol at a concentration of 10⁻⁵ M. The incubated suspensions were filtered on Whatman GF/C, and the filters were washed three times with 5 ml of Krebs Tris-HCl buffer pH 7.7 at 0° C.

The radioactivity of the filters was measured by liquid scintillation. The affinity of the test product for beta₁ -adrenergic receptors is given relative to propanolol as the reference product.

CD=concentration of propanolol inhibiting 50% of the specific binding of [³ H]dihydroalprenolol.

CX=concentration of the test product inhibiting 50% of the specific binding of [.sup. H]dihydroalprenolol.

The relative affinity is given by the relation ##EQU1##

The following results were obtained:

    ______________________________________                                         Product of                                                                     Example       ARL in %                                                         ______________________________________                                         28            28                                                               34            44                                                               48            20                                                               ______________________________________                                    

It is observed that the products of the invention possess exceptional affinity for beta₁ -adrenergic receptors.

3. Affinity for beta₂ -adrenergic receptors

The technique was modelled on that of Mohler et al [Science, Vol. 198, p. 849-851 (1977)]. The cerebella removed from the brains of male rats weighing 150 g on average were homogenized in 90 ml of 0.32M sucrose and after centrifugation of the homogenized mixture at 1,000 g for 20 minutes at 0° C., the supernatant was centrifuged at 30,000 g for 15 minutes at 0° to +4° C. The pellet was suspended in 120 ml of 50 mM Tris-HCl buffer pH 7.7, and centrifuged at 30,000 g for 15 minutes at 0° to +4° C. The new pellet was suspended in 480 ml of 50 mM Krebs Tris-HCl buffer pH 7.7. 2 ml of suspension were then incubated for 10 minutes at 37° C. in the presence of [³ H]dihydroalprenolol at a concentration of 10⁻⁹ M, i) alone, ii) with increasing concentrations of the test product or iii) to determine the non-specific binding, with non-radio active propranolol at a concentration of 10⁻⁵ M. The incubated suspensions were filtered on Whatman GF/C, and the filters were washed three times with 5 ml of Krebs Tris-HCl buffer pH 7.7 at 0° C.

The radioactivity of the filters was measured by liquid scintillation. The affinity of the test product for beta₂ -adrenergic receptors was given relative to propanolol as the reference product.

CD=concentration of propanolol inhibiting 50% of the specific binding of [³ H]dihydroalprenolol.

CX=concentration of the test product inhibiting 50% of the specific binding of [³ H]dihydroalprenolol.

The relative affinity is given by the relation ARL=100 CD/CX

The following results were obtained.

    ______________________________________                                         Product of                                                                     Example       ARL in %                                                         ______________________________________                                         28            15                                                               34            81                                                               48            27                                                               ______________________________________                                    

It is observed that the products of the invention possess exceptional affinity for beta₂ -adrenergic receptors

4. Test of calcium-antagonistic activity in vitro

Rat caudal arteries were cut into a spiral connected to tension gauges and maintained in cells containing 25 ml of Krebs sodium bicarbonate buffer (NaCl: 120.8 nM; KCL: 5.9 mM; MgCl₂ : 1.2 mM; NaH₂ PO₄ : 1.2 mM; NaHCO₃ : 15.5 mM; glucose: 12.6 mM) at 37° C., gassed with a 95% O₂ /5% CO₂ mixture. The preparations were depolarized with a buffer solution containing K⁺ ions at a concentration of 100 mM (NaCl: 26.7 mM; KCL: 100 mM; MgCl₂ : 1.2 mM; NaH₂ PO₄ ; 1.2 mM; NaHCO₃ : 15.5 mM; glucose: 12.6 mM). Calcium chloride was added in a volume of 250 μl to obtain a series of increasing concentrations of Ca²⁺ ions ranging from 0.1 to 3.0 mM. The contractions of the arteries were recorded and a control series were thus established. The operation was repeated with the series of CA²⁺ ions every 15 minutes and the preparation was washed four times after each series. When a stable response was obtained, the operation with the series of CA²⁺ ions was performed in the presence of different concentrations of the test product, until a stable response was obtained.

The contractions of the arteries depend on the entry of Ca²⁺ ions into the cells of the smooth muscles, and were caused by the depolarization of the smooth muscle by the K⁺ ions and by the action of the noradrenaline released at presynaptic level. By starting the operation again with arteries denervated by the action of 6-OH-dopamine, the specific action due to noradrenaline was eliminated.

The results were expressed as IC₅₀ (inhibitory concentration₅₀), the concentration of the test product which inhibits by 50% the contraction due to K⁺ ions. From the results recorded in the table below, it is observed that the products of the invention possess strong calcium-antagonistic activity.

    ______________________________________                                         Product of                                                                     Example       IC.sub.50 in uM                                                  ______________________________________                                         28            2.5                                                              30            8                                                                31            1.8                                                              32            3.9                                                              33            6.3                                                              34            8.8                                                              35            9                                                                36            0.44                                                             40            8.4                                                              46            0.25                                                             47            2.8                                                              49            3                                                                53            8                                                                54            5.4                                                              ______________________________________                                    

5. Study of the hypotensive activity on anaesthetized normotensive rats

Sprague-Dawley male rats (CR) were anaesthetized intraperitoneally with pentabarbital sodium (60 mg/kg) and a jugular vein was catheterized for the injection of the product, and a cartoid artery was catheterized for recording the arterial blood pressure. The test product was dissolved in 10% ethanol and then injected in a volume of 1 ml/kg. The pressure was noted at times 5 minutes and 30 minutes after the injection of the product. The table below shows the variations expressed as a percentage of the arterial blood pressure after administration of the test product compared with the initial control arterial blood pressure.

    ______________________________________                                                             5 mins after                                                                              30 min. after                                   Example  Dose       administration                                                                            administration                                  ______________________________________                                         17       10 mg/kg   -55        -13                                             ______________________________________                                    

6. Study of the acute toxicity

The lethal doses LD₅₀ of the different compounds tested were evaluated after administration orally to mice. The maximum dose not causing any mortality in 8 days was called the LD₀ and the following results were obtained.

    ______________________________________                                         Product of Example                                                                             LD.sub.0 in mg/kg                                              ______________________________________                                         1               80                                                             2               80                                                             4               >400                                                           5               60                                                             6               200                                                            12              >400                                                           15              ≧400                                                    28              >400                                                           30              80                                                             32              100                                                            33              >400                                                           34              80                                                             44              200                                                            46              400                                                            50              200                                                            ______________________________________                                    

Various modifications of the products and methods of the invention may be made without departing from the spirit or scope thereof and it is to be understood that the invention is intended to be limited only as defined in the appended claims. 

What we claim is:
 1. A compound having the formula ##STR46## wherein either A) R₂ and R₃ are both hydrogen, B is --CONH--, NH being on the indole side, b is hydrogen, a band c together form a second bond between the carbons which bear them, A is ##STR47## and R₁ is hydrogen and R is selected from the group consisting of 1,1-dimethylpropyl, ##STR48## or B) R₂ and R₃ are both hydrogen, B is --CO--NH--, NH being on the indole side, b is hydrogen and a and c together form a second bond between the carbons which bear the, A is --(CH₂)₃ --, R₁ is hydrogen and R is selected from the group consisting of 1,1-dimethylpropyl, cyclohexyl, cyclohexylmethyl, propyl, isopropyl and ##STR49## C) or R₂ and R₃ are both hydrogen, B is NH-CO, ##STR50## being on the indole side, b is hydrogen and a and c together form a second bond between the carbons which bear them, A is --(CH₂)₃ --, R₁ is hydrogen and R is selected from the group consisting of cyclopentyl, cyclohexyl, 1,1-dimethylpropyl and ##STR51## D) or R₂ and R₃ are hydrogen, B is --NH--CO--, --NH being on the indole side, b is hydrogen and a and c together form a second bond between the carbons which bear them, A is --(CH₂)₄ --, R₁ is hydrogen and R is 1,1-dimethylethyl E) or R₂ is methyl and R₃ is hydrogen, B is --NH--CO--, NH being on the indole side, b is hydrogen and a and c together form a second bond between the carbons which bear them, A is ##STR52## R₁ is hydrogen and R is 1,1-dimethylethyl, or R₁ and R form, with the nitrogen atom to which they are attached ##STR53## in which Z is ##STR54## n₁ is 1,2 or 3 and X, X₁, X₂, X₃, X₄, X₅ and X₆ are individually selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 3 carbon atoms, halogen, nitro, amino, monoalkylamino or dialkylamino radical, with the proviso that X, X₁ and X₂ are not all three hydrogen, A is --(CH₂)_(n) -- n is 2, 3, 4 or 5 or ##STR55## in which m is 1, 2 or 3, B is --CO--NH-- or --NH--CO--, R₃ is hydrogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 3 carbon atoms, chlorine, bromine or iodine, nitro or amino optionally substituted with an aliphatic acyl of 2 to 5 carbon atoms or with alkyl of 1 to 5 carbon atoms, a together with b is an oxo group, or together with c is a second bond between the carbons which bear them, b is hydrogen or together with a oxo, c is hydrogen or together with a is a second bond between the carbons which bear them, and R₂ is hydrogen, alkyl of 1 to 5 carbon atoms, alkenyl or alkynyl of 2 to 5 carbon atoms or aralkyl of 7 to 12 carbon atoms optionally substituted with 1, 2 or 3 members of the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, methylthio, amino and nitro or cycloalkylalkyl of 4 to 7 carbon atoms.
 2. A compound having the formula ##STR56## wherein one of X or Y is selected from the group consisting of alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 3 carbon atoms, chlorine, bromine, iodine, --NO₂, amino optionally substituted with acyl of 2 to 5 carbon atoms or one or two alkyls of 1 to 5 carbon atoms and the other is hydrogen and their non-toxic, pharmaceutically acceptable acid addition salts.
 3. A compound of claim 2 wherein Y is hydrogen and X is --OCH₃, --NO₂, amino or acetylamino.
 4. A compound of claim 2 wherein X is hydrogen and Y is chlorine, --NO₂, amino or acetylamino.
 5. A compound of claim 1 selected from the group consisting of 2-[2[(1,1-dimethylethyl)amino]ethoxy]-N-(1H-indol-4-yl)benzamide, and its non-toxic, pharmaceutically acceptable acid addition salts.
 6. A compound of claim 1 selected from the group consisting of [2-[3-(1,1-dimethylethyl)amino[-2-hydroxypropoxy]-N-(1H-indol-4yl) benzamide, and its non-toxic, pharmaceutically acceptable acid addition salts.
 7. A compound of claim 1 selected from the group consisting of 2-[3-[[bis-(1-methylethyl]amino]-2-hydroxypropoxyl]-N-(1H-indol-4-yl) benzamide, and its non-toxic, pharmaceutically acceptable acid addition salts.
 8. A compound of claim 1 selected from the group consisting of 2-[3-[(1,1-dimethylethyl)amino]propoxy]-N-(1H-indol-4-yl)benzamide and its non-toxic, pharmaceutically acceptable acid addition salts.
 9. A compound of claim 1 selected from the group consisting of 2-[3-[(1,1-dimethylpropyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl) benzamide and its non-toxic, pharmaceutically acceptable acid addition salts.
 10. A compound of claim 1 selected from the group consisting of 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-N-(1-methyl-1 H-indol-4-yl)benzamide and its non-toxic, pharmaceutically acceptable acid addition salts.
 11. A compound of claim 1 selected from the group consisting of 2-[2-hydroxy-3-[(1,1,3,3-tetramethylbutyl)amino]-propoxy]-N-(1H-indol-4-yl)benzamide and its non-toxic, pharmaceutically acceptable acid addition salts.
 12. A compound of claim 2 selected from the group consisting of 2-[3-(1,1-dimethylethyl)-amino]-2-hydroxy-propoxy-N-(1H-indol-4-yl)benzamide and its non-toxic, pharmaceutically acceptable acid addition salts.
 13. An antiarrythmic composition comprising an antiarrythmically effective amount of at least one compound of claim 2 and an inert pharmaceutical carrier.
 14. A composition of claim 5 wherein R₂ is hydrogen.
 15. A composition of claim 6 wherein a and c form a carbon-carbon bond.
 16. A composition of claim 5 wherein R₃ is hydrogen.
 17. A composition of claim 5 wherein ##STR57## in the ortho position with respect to b.
 18. A composition of claim 5 wherein B is --NH--CO-- with NH next to the indole.
 19. A composition of claim 13 wherein the active compound is selected from the group consisting of 2-[2-[2-[1,1-dimethylethyl)amino]ethoxy]-N-(1H-indol-4-yl)benzamide, and its non-toxic, pharmaceutically acceptable acid addition salts.
 20. A composition of claim 13 wherein the active compound is selected from the group consisting of 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4yl)benzamide, and its non-toxic, pharmaceutically acceptable acid addition salts.
 21. A composition of claim 13 wherein the active compound is selected from the group consisting of 2-[3-[(bis-(1-methylethyl)amino]-2-hydoxypropoxy]-N-(1H-indol-4-yl)-benzamide, and its non-toxic, pharmaceutically acceptable acid addition salts.
 22. A composition of claim 13 wherein the active compound is selected from the group consisting of 2-[3-[(1,1-dimethylethyl)amino]propoxy]-N-(1H-indol-4-yl)benzamide, and its non-toxic, pharmaceutically acceptable acid addition salts.
 23. A method of inducing antiarrythmic activity in warm-blooded animals comprising administering to warm-blooded animals an anti-arrythimcally effective amount of at least one compound of claim
 1. 24. A method of claim 23 wherein in the active compound R₁ and R₂ are both hydrogen.
 25. A method of claim 24 wherein in the active compound a and c form a carbon-carbon bond.
 26. A method of claim 23 wherein in the active compound R₂ is hydrogen.
 27. A method of claim 23 wherein in the active compound ##STR58## in the ortho position with respect to b.
 28. A method of claim 23 wherein in the active compound B is --NH--CO-- with NH next to the indole.
 29. A method of claim 25 wherein the active compound is selected from the group consisting of 2-[2-(1,1-dimethylethyl)amino]ethoxy]-N-(1H-indol-4-yl)benzamide, and its non-toxic, pharmaceutically acceptable acid addition salts.
 30. A method of claim 25 wherein the active compound is selected from the group consisting of 2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-N-(1H-indol-4yl)benzamide, and its non-toxic, pharmaceutically acceptable acid addition salts.
 31. A method of claim 25 wherein the active compound is selected from the group consisting of 2-[3-[[bis-(1-methylethyl]amino]-2-hydroxypropoxy]-N-(1H-indol-4-yl)benzamide and its non-toxic, pharmaceutically acceptable acid addition salts.
 32. A method of claim 25 wherein the active compound is selected from the group consisting of 2-[3-[(1,1-dimethylethyl)amino]amino]propoxy]-N-(1H-indol-4yl)benzamide, and its non-toxic, pharmaceutically acceptable acid addition salts.
 33. A method of claim 23 wherein R is hydrogen.
 34. A method of claim 23 wherein a and c form a carbon-carbon bond.
 35. A method of claim 23 wherein R is hydrogen.
 36. A method of claim 23 wherein ##STR59## is in the ortho position with respect to b.
 37. A method of claim 23 wherein B is ##STR60## with NH next to the indole. 